Brakenhoff JP - Search Results

1

Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.

de Hon FD, Klaasse Bos HK, Ebeling SB, Grötzinger J, Kurapkat G, Rose-John S, Aarden LA, Brakenhoff JP. de Hon FD, et al. Among authors: brakenhoff jp. FEBS Lett. 1995 Aug 7;369(2-3):187-91. doi: 10.1016/0014-5793(95)00741-q. FEBS Lett. 1995. PMID: 7649255 Free article.

2

Development of human IL-6 receptor antagonists.

Brakenhoff JP, de Hon FD, Aarden LA. Brakenhoff JP, et al. Ann N Y Acad Sci. 1995 Jul 21;762:129-34; discussion 135. doi: 10.1111/j.1749-6632.1995.tb32321.x. Ann N Y Acad Sci. 1995. PMID: 7668524 Review.

3

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.

de Hon FD, Ehlers M, Rose-John S, Ebeling SB, Bos HK, Aarden LA, Brakenhoff JP. de Hon FD, et al. Among authors: brakenhoff jp. J Exp Med. 1994 Dec 1;180(6):2395-400. doi: 10.1084/jem.180.6.2395. J Exp Med. 1994. PMID: 7964514 Free PMC article.

4

Development of a human interleukin-6 receptor antagonist.

Brakenhoff JP, de Hon FD, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich PC, Content J, Aarden LA. Brakenhoff JP, et al. J Biol Chem. 1994 Jan 7;269(1):86-93. J Biol Chem. 1994. PMID: 8276883 Free article.

5

Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.

Brakenhoff JP, Bos HK, Grötzinger J, Rose-John S, Aarden LA. Brakenhoff JP, et al. FEBS Lett. 1996 Oct 21;395(2-3):235-40. doi: 10.1016/0014-5793(96)00974-x. FEBS Lett. 1996. PMID: 8898103 Free article.

6

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

Brakenhoff JP, Hart M, De Groot ER, Di Padova F, Aarden LA. Brakenhoff JP, et al. J Immunol. 1990 Jul 15;145(2):561-8. J Immunol. 1990. PMID: 1694882

7

Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28.

Brakenhoff JP, Hart M, Aarden LA. Brakenhoff JP, et al. J Immunol. 1989 Aug 15;143(4):1175-82. J Immunol. 1989. PMID: 2663992

8

Interleukin 6 is involved in interleukin 1-induced activities.

Helle M, Brakenhoff JP, De Groot ER, Aarden LA. Helle M, et al. Among authors: brakenhoff jp. Eur J Immunol. 1988 Jun;18(6):957-9. doi: 10.1002/eji.1830180619. Eur J Immunol. 1988. PMID: 3260188

9

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

Ehlers M, Grötzinger J, deHon FD, Müllberg J, Brakenhoff JP, Liu J, Wollmer A, Rose-John S. Ehlers M, et al. Among authors: brakenhoff jp. J Immunol. 1994 Aug 15;153(4):1744-53. J Immunol. 1994. PMID: 7519211

10

Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.

Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. Among authors: brakenhoff jp. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920 Free article.

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