Doherty AM - Search Results

1

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al. Doherty AM, et al. J Med Chem. 1995 Apr 14;38(8):1259-63. doi: 10.1021/jm00008a002. J Med Chem. 1995. PMID: 7731010 No abstract available.

2

Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).

Massa MA, Patt WC, Ahn K, Sisneros AM, Herman SB, Doherty A. Massa MA, et al. Among authors: doherty a. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2117-22. doi: 10.1016/s0960-894x(98)00375-8. Bioorg Med Chem Lett. 1998. PMID: 9873497

3

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: doherty am. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

4

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: doherty am. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

5

Structure-activity relationships of a novel series of orally active nonpeptide ETA and ETA/B endothelin receptor-selective antagonists.

Doherty AM, Patt WC, Repine J, Edmunds JJ, Berryman KA, Reisdorph BR, Walker DM, Haleen SJ, Keiser JA, Flynn MA, et al. Doherty AM, et al. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S358-61. J Cardiovasc Pharmacol. 1995. PMID: 8587414

6

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM. Patt WC, et al. Among authors: doherty am. J Med Chem. 1997 Mar 28;40(7):1063-74. doi: 10.1021/jm9606507. J Med Chem. 1997. PMID: 9089328

7

Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.

Cody WL, He JX, Reily MD, Haleen SJ, Walker DM, Reyner EL, Stewart BH, Doherty AM. Cody WL, et al. Among authors: doherty am. J Med Chem. 1997 Jul 4;40(14):2228-40. doi: 10.1021/jm970161m. J Med Chem. 1997. PMID: 9216842

8

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

Berryman KA, Edmunds JJ, Bunker AM, Haleen S, Bryant J, Welch KM, Doherty AM. Berryman KA, et al. Among authors: doherty am. Bioorg Med Chem. 1998 Sep;6(9):1447-56. doi: 10.1016/s0968-0896(98)00080-7. Bioorg Med Chem. 1998. PMID: 9801816

9

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.

Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD. Plummer JS, et al. Among authors: doherty am. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3409-14. doi: 10.1016/s0960-894x(98)00613-1. Bioorg Med Chem Lett. 1998. PMID: 9873743

10

Butenolide endothelin antagonists with improved aqueous solubility.

Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA. Patt WC, et al. Among authors: doherty am. J Med Chem. 1999 Jun 17;42(12):2162-8. doi: 10.1021/jm980504w. J Med Chem. 1999. PMID: 10377221

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