Fry DW - Search Results

1

Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.

Palmer BD, Rewcastle GW, Thompson AM, Boyd M, Showalter HD, Sercel AD, Fry DW, Kraker AJ, Denny WA. Palmer BD, et al. Among authors: fry dw. J Med Chem. 1995 Jan 6;38(1):58-67. doi: 10.1021/jm00001a011. J Med Chem. 1995. PMID: 7837241

2

Strategies for the discovery of novel tyrosine kinase inhibitors with anticancer activity.

Fry DW, Kraker AJ, Connors RC, Elliott WL, Nelson JM, Showalter HD, Leopold WR. Fry DW, et al. Anticancer Drug Des. 1994 Aug;9(4):331-51. Anticancer Drug Des. 1994. PMID: 7916900

3

Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).

Rewcastle GW, Palmer BD, Dobrusin EM, Fry DW, Kraker AJ, Denny WA. Rewcastle GW, et al. Among authors: fry dw. J Med Chem. 1994 Jun 24;37(13):2033-42. doi: 10.1021/jm00039a016. J Med Chem. 1994. PMID: 8027985

4

Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids).

Thompson AM, Rewcastle GW, Tercel M, Dobrusin EM, Fry DW, Kraker AJ, Denny WA. Thompson AM, et al. Among authors: fry dw. J Med Chem. 1993 Aug 20;36(17):2459-69. doi: 10.1021/jm00069a003. J Med Chem. 1993. PMID: 8355247

5

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA. Bridges AJ, et al. Among authors: fry dw. J Med Chem. 1996 Jan 5;39(1):267-76. doi: 10.1021/jm9503613. J Med Chem. 1996. PMID: 8568816

6

Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Thompson AM, Bridges AJ, Cody DR, Zhou H, Fry DW, McMichael A, Denny WA. Rewcastle GW, et al. Among authors: fry dw. J Med Chem. 1996 Apr 26;39(9):1823-35. doi: 10.1021/jm9508651. J Med Chem. 1996. PMID: 8627606

7

Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Bridges AJ, Showalter HD, Sun L, Nelson J, McMichael A, Kraker AJ, Fry DW, Denny WA. Rewcastle GW, et al. Among authors: fry dw. J Med Chem. 1996 Feb 16;39(4):918-28. doi: 10.1021/jm950692f. J Med Chem. 1996. PMID: 8632415

8

Structure-activity relationships for 4-anilinoquinazolines as potent inhibitors at the ATP binding site of the epidermal growth factor receptor in vitro.

Denny WA, Rewcastle GW, Bridges AJ, Fry DW, Kraker AJ. Denny WA, et al. Among authors: fry dw. Clin Exp Pharmacol Physiol. 1996 May;23(5):424-7. doi: 10.1111/j.1440-1681.1996.tb02752.x. Clin Exp Pharmacol Physiol. 1996. PMID: 8713682

9

Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.

Showalter HD, Sercel AD, Leja BM, Wolfangel CD, Ambroso LA, Elliott WL, Fry DW, Kraker AJ, Howard CT, Lu GH, Moore CW, Nelson JM, Roberts BJ, Vincent PW, Denny WA, Thompson AM. Showalter HD, et al. Among authors: fry dw. J Med Chem. 1997 Feb 14;40(4):413-26. doi: 10.1021/jm960689b. J Med Chem. 1997. PMID: 9046331

10

Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding.

Palmer BD, Trumpp-Kallmeyer S, Fry DW, Nelson JM, Showalter HD, Denny WA. Palmer BD, et al. Among authors: fry dw. J Med Chem. 1997 May 9;40(10):1519-29. doi: 10.1021/jm960789h. J Med Chem. 1997. PMID: 9154973

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