Tom J - Search Results

1

A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues.

Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA. Jackson DY, et al. Among authors: tom j. Science. 1994 Oct 14;266(5183):243-7. doi: 10.1126/science.7939659. Science. 1994. PMID: 7939659

2

Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.

Abrahmsén L, Tom J, Burnier J, Butcher KA, Kossiakoff A, Wells JA. Abrahmsén L, et al. Among authors: tom j. Biochemistry. 1991 Apr 30;30(17):4151-9. doi: 10.1021/bi00231a007. Biochemistry. 1991. PMID: 2021606

3

Minimization of a polypeptide hormone.

Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. Li B, et al. Among authors: tom jy. Science. 1995 Dec 8;270(5242):1657-60. doi: 10.1126/science.270.5242.1657. Science. 1995. PMID: 7502074

4

Designing subtilisin BPN' to cleave substrates containing dibasic residues.

Ballinger MD, Tom J, Wells JA. Ballinger MD, et al. Among authors: tom j. Biochemistry. 1995 Oct 17;34(41):13312-9. doi: 10.1021/bi00041a006. Biochemistry. 1995. PMID: 7577915

5

Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates.

Ballinger MD, Tom J, Wells JA. Ballinger MD, et al. Among authors: tom j. Biochemistry. 1996 Oct 22;35(42):13579-85. doi: 10.1021/bi961543h. Biochemistry. 1996. PMID: 8885837

6

Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site.

Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JY, Wells JA, Cunningham BC. Fairbrother WJ, et al. Among authors: tom jy. Biochemistry. 1998 Dec 22;37(51):17754-64. doi: 10.1021/bi981931e. Biochemistry. 1998. PMID: 9922141

7

The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction.

Nusrat A, Chen JA, Foley CS, Liang TW, Tom J, Cromwell M, Quan C, Mrsny RJ. Nusrat A, et al. Among authors: tom j. J Biol Chem. 2000 Sep 22;275(38):29816-22. doi: 10.1074/jbc.M002450200. J Biol Chem. 2000. PMID: 10887180 Free article.

8

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, Halladay J, Hymowitz SG, La H, LoRusso P, Maurer B, Murray L, Plise E, Quan C, Stephan JP, Young SG, Tom J, Tsui V, Um J, Varfolomeev E, Vucic D, Wagner AJ, Wallweber HJ, Wang L, Ware J, Wen Z, Wong H, Wong JM, Wong M, Wong S, Yu R, Zobel K, Fairbrother WJ. Flygare JA, et al. Among authors: tom j. J Med Chem. 2012 May 10;55(9):4101-13. doi: 10.1021/jm300060k. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22413863 Free PMC article.

9

Structural and functional analysis of HtrA1 and its subdomains.

Eigenbrot C, Ultsch M, Lipari MT, Moran P, Lin SJ, Ganesan R, Quan C, Tom J, Sandoval W, van Lookeren Campagne M, Kirchhofer D. Eigenbrot C, et al. Among authors: tom j. Structure. 2012 Jun 6;20(6):1040-50. doi: 10.1016/j.str.2012.03.021. Epub 2012 May 10. Structure. 2012. PMID: 22578544 Free article.

10

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.

Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Krylova I, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN. Stanger K, et al. Among authors: tom j. Nat Chem Biol. 2012 Jul;8(7):655-60. doi: 10.1038/nchembio.967. Epub 2012 Jun 10. Nat Chem Biol. 2012. PMID: 22683611

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