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A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.
Hwang SY, Hertzog PJ, Holland KA, Sumarsono SH, Tymms MJ, Hamilton JA, Whitty G, Bertoncello I, Kola I. Hwang SY, et al. Among authors: tymms mj. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11284-8. doi: 10.1073/pnas.92.24.11284. Proc Natl Acad Sci U S A. 1995. PMID: 7479980 Free PMC article.
A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and Is necessary for transcriptional activation of interferon-regulated genes.
Holland KA, Owczarek CM, Hwang SY, Tymms MJ, Constantinescu SN, Pfeffer LM, Kola I, Hertzog PJ. Holland KA, et al. Among authors: tymms mj. J Biol Chem. 1997 Aug 22;272(34):21045-51. doi: 10.1074/jbc.272.34.21045. J Biol Chem. 1997. PMID: 9261106 Free article.
47 results