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Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2007 Jun 14;50(12):2779-86. doi: 10.1021/jm061369n. Epub 2007 May 22. J Med Chem. 2007. PMID: 17516639 Free PMC article.
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2008 Mar 13;51(5):1369-76. doi: 10.1021/jm070332f. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266313 Free PMC article.
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2008 Oct 23;51(20):6334-47. doi: 10.1021/jm800389v. Epub 2008 Sep 27. J Med Chem. 2008. PMID: 18821747 Free PMC article.
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2010 Aug 12;53(15):5491-501. doi: 10.1021/jm100157m. J Med Chem. 2010. PMID: 20617791 Free PMC article.
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. Among authors: yamamura hi. J Med Chem. 2011 Apr 14;54(7):2029-38. doi: 10.1021/jm101023r. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366266 Free PMC article.
500 results