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1

Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplasty.

van den Bos AA, Deckers JW, Heyndrickx GR, Laarman GJ, Suryapranata H, Zijlstra F, Close P, Rijnierse JJ, Buller HR, Serruys PW. van den Bos AA, et al. Among authors: close p. Circulation. 1993 Nov;88(5 Pt 1):2058-66. doi: 10.1161/01.cir.88.5.2058. Circulation. 1993. PMID: 8222099 Clinical Trial.

2

Evaluation of recombinant hirudin (CGP 39,393/TMREVASC) in the prevention of restenosis after percutaneous transluminal coronary angioplasty. Rationale and design of the HELVETICA trial, a multicentre randomized double blind heparin controlled study.

Herrman JP, Simon R, Umans VA, Peerboom PF, Keane D, Rijnierse JJ, Bach D, Kobi P, Kerry R, Close P, et al. Herrman JP, et al. Among authors: close p. Eur Heart J. 1995 Nov;16 Suppl L:56-62. doi: 10.1093/eurheartj/16.suppl_l.56. Eur Heart J. 1995. PMID: 8869020 Review.

3

Biologic effects of recombinant hirudin (CGP 39393) in human volunteers. European Hirudin in Thrombosis Group.

Verstraete M, Nurmohamed M, Kienast J, Siebeck M, Silling-Engelhardt G, Büller H, Hoet B, Bichler J, Close P. Verstraete M, et al. Among authors: close p. J Am Coll Cardiol. 1993 Oct;22(4):1080-8. doi: 10.1016/0735-1097(93)90419-2. J Am Coll Cardiol. 1993. PMID: 8409044 Free article.

4

[Profibrinolytic activity of recombinant hirudin?].

Tsakiris DA, Meyer D, Fabbri J, Close P, Marbet GA. Tsakiris DA, et al. Among authors: close p. Schweiz Med Wochenschr. 1991 Mar 9;121(10):338-40. Schweiz Med Wochenschr. 1991. PMID: 2028237 German.

5

Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393.

Eriksson BI, Ekman S, Kalebo P, Zachrisson B, Bach D, Close P. Eriksson BI, et al. Among authors: close p. Lancet. 1996 Mar 9;347(9002):635-9. doi: 10.1016/s0140-6736(96)91200-3. Lancet. 1996. PMID: 8596376 Clinical Trial.

6

Clinical pharmacology of intravenously administered recombinant desulfatohirudin (CGP 39393) in healthy volunteers.

Marbet GA, Verstraete M, Kienast J, Graf P, Hoet B, Tsakiris DA, Silling-Engelhardt G, Close P. Marbet GA, et al. Among authors: close p. J Cardiovasc Pharmacol. 1993 Sep;22(3):364-72. doi: 10.1097/00005344-199309000-00004. J Cardiovasc Pharmacol. 1993. PMID: 7504125 Clinical Trial.

7

Direct thrombin inhibition with Rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement.

Eriksson BI, Kälebo P, Ekman S, Lindbratt S, Kerry R, Close P. Eriksson BI, et al. Among authors: close p. Thromb Haemost. 1994 Aug;72(2):227-31. Thromb Haemost. 1994. PMID: 7831657 Clinical Trial.

8

Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement.

Eriksson BI, Ekman S, Lindbratt S, Baur M, Bach D, Torholm C, Kälebo P, Close P. Eriksson BI, et al. Among authors: close p. J Bone Joint Surg Am. 1997 Mar;79(3):326-33. doi: 10.2106/00004623-199703000-00002. J Bone Joint Surg Am. 1997. PMID: 9070519 Clinical Trial.

9

A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement.

Eriksson BI, Wille-Jørgensen P, Kälebo P, Mouret P, Rosencher N, Bösch P, Baur M, Ekman S, Bach D, Lindbratt S, Close P. Eriksson BI, et al. Among authors: close p. N Engl J Med. 1997 Nov 6;337(19):1329-35. doi: 10.1056/NEJM199711063371901. N Engl J Med. 1997. PMID: 9358126 Free article. Clinical Trial.

10

Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers. The European Hirudin in Thrombosis Group (HIT Group).

Close P, Bichler J, Kerry R, Ekman S, Bueller HR, Kienast J, Marbet GA, Schramm W, Verstraete M. Close P, et al. Coron Artery Dis. 1994 Nov;5(11):943-9. Coron Artery Dis. 1994. PMID: 7719527 Clinical Trial.

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