Stein PD - Search Results

1

The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, Liu EC, Webb ML, Murugesan N, Dickey J, et al. Stein PD, et al. J Med Chem. 1994 Feb 4;37(3):329-31. doi: 10.1021/jm00029a001. J Med Chem. 1994. PMID: 8308857 No abstract available.

2

Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.

Murugesan N, Gu Z, Stein PD, Spergel S, Bisaha S, Liu EC, Zhang R, Webb ML, Moreland S, Barrish JC. Murugesan N, et al. Among authors: stein pd. Bioorg Med Chem Lett. 2002 Feb 25;12(4):517-20. doi: 10.1016/s0960-894x(01)00791-0. Bioorg Med Chem Lett. 2002. PMID: 11844662

3

BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist.

Webb ML, Bird JE, Liu EC, Rose PM, Serafino R, Stein PD, Moreland S. Webb ML, et al. Among authors: stein pd. J Pharmacol Exp Ther. 1995 Mar;272(3):1124-34. J Pharmacol Exp Ther. 1995. PMID: 7891325

4

Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity.

Webb ML, Patel PS, Rose PM, Liu EC, Stein PD, Barrish J, Lach DA, Stouch T, Fisher SM, Hadjilambris O, Lee H, Skwish S, Dickinson KE, Krystek SR Jr. Webb ML, et al. Among authors: stein pd. Biochemistry. 1996 Feb 27;35(8):2548-56. doi: 10.1021/bi951836v. Biochemistry. 1996. PMID: 8611558

5

Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).

Murugesan N, Gu Z, Stein PD, Bisaha S, Spergel S, Girotra R, Lee VG, Lloyd J, Misra RN, Schmidt J, Mathur A, Stratton L, Kelly YF, Bird E, Waldron T, Liu EC, Zhang R, Lee H, Serafino R, Abboa-Offei B, Mathers P, Giancarli M, Seymour AA, Webb ML, Hunt JT, et al. Murugesan N, et al. Among authors: stein pd. J Med Chem. 1998 Dec 17;41(26):5198-218. doi: 10.1021/jm970872k. J Med Chem. 1998. PMID: 9857090

6

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.

Murugesan N, Gu Z, Stein PD, Spergel S, Mathur A, Leith L, Liu EC, Zhang R, Bird E, Waldron T, Marino A, Morrison RA, Webb ML, Moreland S, Barrish JC. Murugesan N, et al. Among authors: stein pd. J Med Chem. 2000 Aug 10;43(16):3111-7. doi: 10.1021/jm000105c. J Med Chem. 2000. PMID: 10956219

7

Discovery and structure-activity relationships of sulfonamide ETA-selective antagonists.

Stein PD, Floyd DM, Bisaha S, Dickey J, Girotra RN, Gougoutas JZ, Kozlowski M, Lee VG, Liu EC, Malley MF, et al. Stein PD, et al. J Med Chem. 1995 Apr 14;38(8):1344-54. doi: 10.1021/jm00008a013. J Med Chem. 1995. PMID: 7731020

8

Three-dimensional quantitative structure-activity relationships of sulfonamide endothelin inhibitors.

Krystek SR Jr, Hunt JT, Stein PD, Stouch TR. Krystek SR Jr, et al. Among authors: stein pd. J Med Chem. 1995 Feb 17;38(4):659-68. doi: 10.1021/jm00004a012. J Med Chem. 1995. PMID: 7861414

9

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.

Shi Y, Zhang J, Stein PD, Shi M, O'Connor SP, Bisaha SN, Li C, Atwal KS, Bisacchi GS, Sitkoff D, Pudzianowski AT, Liu EC, Hartl KS, Seiler SM, Youssef S, Steinbacher TE, Schumacher WA, Rendina AR, Bozarth JM, Peterson TL, Zhang G, Zahler R. Shi Y, et al. Among authors: stein pd. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5453-8. doi: 10.1016/j.bmcl.2005.08.107. Epub 2005 Oct 5. Bioorg Med Chem Lett. 2005. PMID: 16213711

10

Synthesis and evaluation of acylguanidine FXa inhibitors.

O'Connor SP, Atwal K, Li C, Liu EC, Seiler SM, Shi M, Shi Y, Stein PD, Wang Y. O'Connor SP, et al. Among authors: stein pd. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4696-9. doi: 10.1016/j.bmcl.2008.07.004. Epub 2008 Jul 5. Bioorg Med Chem Lett. 2008. PMID: 18644722

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