The anti-progestin RU486 stabilizes the progestin-induced fatty acid synthetase mRNA but does not stimulate its transcription.
Chalbos D, Galtier F, Emiliani S, Rochefort H.
Chalbos D, et al.
J Biol Chem. 1991 May 5;266(13):8220-4.
J Biol Chem. 1991.
PMID: 2022639
Free article.
Progestins induce fatty acid synthetase (FAS) in breast cancer cell lines, both increasing its gene transcription and mRNA stabilization (Joyeux, C., Rochefort, H., and Chalbos, D. (1989) Mol. Endocrinol. 4, 681-686). In vitro run-on transcription assays show that R …
Progestins induce fatty acid synthetase (FAS) in breast cancer cell lines, both increasing its gene transcription and mRNA stabilization (Jo …