Hodges JC - Search Results

1

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).

Sircar I, Hodges JC, Quin J 3rd, Bunker AM, Winters RT, Edmunds JJ, Kostlan CR, Connolly C, Kesten SJ, Hamby JM, et al. Sircar I, et al. Among authors: hodges jc. J Med Chem. 1993 Aug 6;36(16):2253-65. doi: 10.1021/jm00068a002. J Med Chem. 1993. PMID: 8360871

2

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

Blankley CJ, Hodges JC, Klutchko SR, Himmelsbach RJ, Chucholowski A, Connolly CJ, Neergaard SJ, Van Nieuwenhze MS, Sebastian A, Quin J 3rd, et al. Blankley CJ, et al. Among authors: hodges jc. J Med Chem. 1991 Nov;34(11):3248-60. doi: 10.1021/jm00115a014. J Med Chem. 1991. PMID: 1956044

3

Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.

Repine JT, Himmelsbach RJ, Hodges JC, Kaltenbronn JS, Sircar I, Skeean RW, Brennan ST, Hurley TR, Lunney E, Humblet CC, et al. Repine JT, et al. Among authors: hodges jc. J Med Chem. 1991 Jul;34(7):1935-43. doi: 10.1021/jm00111a002. J Med Chem. 1991. PMID: 2066966

4

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al. Edmunds JJ, et al. Among authors: hodges jc. J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005. J Med Chem. 1995. PMID: 7562906

5

Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.

Keiser JA, Ryan MJ, Panek RL, Hodges JC, Sircar I. Keiser JA, et al. Among authors: hodges jc. J Pharmacol Exp Ther. 1995 Mar;272(3):963-9. J Pharmacol Exp Ther. 1995. PMID: 7891350

6

New inhibitors of human renin that contain novel replacements at the P2 site.

Doherty AM, Kaltenbronn JS, Hudspeth JP, Repine JT, Roark WH, Sircar I, Tinney FJ, Connolly CJ, Hodges JC, Taylor MD, et al. Doherty AM, et al. Among authors: hodges jc. J Med Chem. 1991 Apr;34(4):1258-71. doi: 10.1021/jm00108a004. J Med Chem. 1991. PMID: 1901910

7

Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase.

Leonard DM, Shuler KR, Poulter CJ, Eaton SR, Sawyer TK, Hodges JC, Su TZ, Scholten JD, Gowan RC, Sebolt-Leopold JS, Doherty AM. Leonard DM, et al. Among authors: hodges jc. J Med Chem. 1997 Jan 17;40(2):192-200. doi: 10.1021/jm960602m. J Med Chem. 1997. PMID: 9003517

8

Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.

Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al. Lunney EA, et al. Among authors: hodges jc. J Med Chem. 1993 Nov 26;36(24):3809-20. doi: 10.1021/jm00076a008. J Med Chem. 1993. PMID: 8254610

9

Subclasses of angiotensin II binding sites and their functional significance.

Dudley DT, Panek RL, Major TC, Lu GH, Bruns RF, Klinkefus BA, Hodges JC, Weishaar RE. Dudley DT, et al. Among authors: hodges jc. Mol Pharmacol. 1990 Sep;38(3):370-7. Mol Pharmacol. 1990. PMID: 2402226

10

Functional studies but not receptor binding can distinguish surmountable from insurmountable AT1 antagonism.

Panek RL, Lu GH, Overhiser RW, Major TC, Hodges JC, Taylor DG. Panek RL, et al. Among authors: hodges jc. J Pharmacol Exp Ther. 1995 May;273(2):753-61. J Pharmacol Exp Ther. 1995. PMID: 7752078

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

69 results

Search Page

Filters