Pigini M - Search Results

1

Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.

Quaglia W, Pigini M, Tayebati SK, Piergentili A, Giannella M, Leonardi A, Taddei C, Melchiorre C. Quaglia W, et al. Among authors: pigini m. J Med Chem. 1996 May 24;39(11):2253-8. doi: 10.1021/jm960069a. J Med Chem. 1996. PMID: 8667368

2

Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.

Gentili F, Bousquet P, Brasili L, Caretto M, Carrieri A, Dontenwill M, Giannella M, Marucci G, Perfumi M, Piergentili A, Quaglia W, Rascente C, Pigini M. Gentili F, et al. Among authors: pigini m. J Med Chem. 2002 Jan 3;45(1):32-40. doi: 10.1021/jm0110082. J Med Chem. 2002. PMID: 11754577

3

Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.

Quaglia W, Pigini M, Piergentili A, Giannella M, Gentili F, Marucci G, Carrieri A, Carotti A, Poggesi E, Leonardi A, Melchiorre C. Quaglia W, et al. Among authors: pigini m. J Med Chem. 2002 Apr 11;45(8):1633-43. doi: 10.1021/jm011066n. J Med Chem. 2002. PMID: 11931617

4

Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.

Gentili F, Bousquet P, Brasili L, Dontenwill M, Feldman J, Ghelfi F, Giannella M, Piergentili A, Quaglia W, Pigini M. Gentili F, et al. Among authors: pigini m. J Med Chem. 2003 May 22;46(11):2169-76. doi: 10.1021/jm021113r. J Med Chem. 2003. PMID: 12747788

5

Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine.

Piergentili A, Gentili F, Ghelfi F, Marucci G, Pigini M, Quaglia W, Giannella M. Piergentili A, et al. Among authors: pigini m. Bioorg Med Chem. 2003 Sep 1;11(18):3901-11. doi: 10.1016/s0968-0896(03)00431-0. Bioorg Med Chem. 2003. PMID: 12927850

6

alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.

Gentili F, Ghelfi F, Giannella M, Piergentili A, Pigini M, Quaglia W, Vesprini C, Crassous PA, Paris H, Carrieri A. Gentili F, et al. Among authors: pigini m. J Med Chem. 2004 Dec 2;47(25):6160-73. doi: 10.1021/jm0408215. J Med Chem. 2004. PMID: 15566287

7

Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation.

Quaglia W, Santoni G, Pigini M, Piergentili A, Gentili F, Buccioni M, Mosca M, Lucciarini R, Amantini C, Nabissi MI, Ballarini P, Poggesi E, Leonardi A, Giannella M. Quaglia W, et al. Among authors: pigini m. J Med Chem. 2005 Dec 1;48(24):7750-63. doi: 10.1021/jm0580398. J Med Chem. 2005. PMID: 16302814

8

Agonists and antagonists targeting the different alpha2-adrenoceptor subtypes.

Gentili F, Pigini M, Piergentili A, Giannella M. Gentili F, et al. Among authors: pigini m. Curr Top Med Chem. 2007;7(2):163-86. doi: 10.2174/156802607779318235. Curr Top Med Chem. 2007. PMID: 17266604 Review.

9

Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.

Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M. Crassous PA, et al. Among authors: pigini m. J Med Chem. 2007 Aug 9;50(16):3964-8. doi: 10.1021/jm061487a. Epub 2007 Jul 14. J Med Chem. 2007. PMID: 17630725

10

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.

Gentili F, Cardinaletti C, Vesprini C, Carrieri A, Ghelfi F, Farande A, Giannella M, Piergentili A, Quaglia W, Laurila JM, Huhtinen A, Scheinin M, Pigini M. Gentili F, et al. Among authors: pigini m. J Med Chem. 2008 Jul 24;51(14):4289-99. doi: 10.1021/jm800250z. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578476

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