Seitz SP - Search Results

1

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: seitz sp. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449

2

Phospholipase C inhibitors: a new class of cytotoxic agents.

Perrella FW, Chen SF, Behrens DL, Kaltenbach RF 3rd, Seitz SP. Perrella FW, et al. Among authors: seitz sp. J Med Chem. 1994 Jul 8;37(14):2232-7. doi: 10.1021/jm00040a016. J Med Chem. 1994. PMID: 8035430

3

Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

Nugiel DA, Jacobs K, Kaltenbach RF, Worley T, Patel M, Meyer DT, Jadhav PK, De Lucca GV, Smyser TE, Klabe RM, Bacheler LT, Rayner MM, Seitz SP. Nugiel DA, et al. Among authors: seitz sp. J Med Chem. 1996 May 24;39(11):2156-69. doi: 10.1021/jm960083n. J Med Chem. 1996. PMID: 8667359

4

Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.

Nugiel DA, Jacobs K, Cornelius L, Chang CH, Jadhav PK, Holler ER, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Logue KA, Gorey-Feret LJ, Lam GN, Erickson-Viitanen S, Seitz SP. Nugiel DA, et al. Among authors: seitz sp. J Med Chem. 1997 May 9;40(10):1465-74. doi: 10.1021/jm960839i. J Med Chem. 1997. PMID: 9154969

5

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.

Rodgers JD, Lam PY, Johnson BL, Wang H, Li R, Ru Y, Ko SS, Seitz SP, Trainor GL, Anderson PS, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Wright MR, Chang CH, Erickson-Viitanen S. Rodgers JD, et al. Among authors: seitz sp. Chem Biol. 1998 Oct;5(10):597-608. doi: 10.1016/s1074-5521(98)90117-x. Chem Biol. 1998. PMID: 9818151

6

Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.

Kaltenbach RF 3rd, Nugiel DA, Lam PY, Klabe RM, Seitz SP. Kaltenbach RF 3rd, et al. Among authors: seitz sp. J Med Chem. 1998 Dec 3;41(25):5113-7. doi: 10.1021/jm980255b. J Med Chem. 1998. PMID: 9836627

7

The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.

Patel M, Bacheler LT, Rayner MM, Cordova BC, Klabe RM, Erickson-Viitanen S, Seitz SP. Patel M, et al. Among authors: seitz sp. Bioorg Med Chem Lett. 1998 Apr 7;8(7):823-8. doi: 10.1016/s0960-894x(98)00119-x. Bioorg Med Chem Lett. 1998. PMID: 9871548

8

The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.

Patel M, Kaltenbach RF 3rd, Nugiel DA, McHugh RJ Jr, Jadhav PK, Bacheler LT, Cordova BC, Klabe RM, Erickson-Viitanen S, Garber S, Reid C, Seitz SP. Patel M, et al. Among authors: seitz sp. Bioorg Med Chem Lett. 1998 May 5;8(9):1077-82. doi: 10.1016/s0960-894x(98)00175-9. Bioorg Med Chem Lett. 1998. PMID: 9871711

9

Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents.

Kaltenbach RF 3rd, Klabe RM, Cordova BC, Seitz SP. Kaltenbach RF 3rd, et al. Among authors: seitz sp. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2259-62. doi: 10.1016/s0960-894x(99)00367-4. Bioorg Med Chem Lett. 1999. PMID: 10465557

10

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.

Patel M, Ko SS, McHugh RJ Jr, Markwalder JA, Srivastava AS, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Seitz SP. Patel M, et al. Among authors: seitz sp. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2805-10. doi: 10.1016/s0960-894x(99)00486-2. Bioorg Med Chem Lett. 1999. PMID: 10522695

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