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Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis.
Tabas I, Marathe S, Keesler GA, Beatini N, Shiratori Y. Tabas I, et al. Among authors: beatini n. J Biol Chem. 1996 Sep 13;271(37):22773-81. doi: 10.1074/jbc.271.37.22773. J Biol Chem. 1996. PMID: 8798453 Free article.
Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation.
Buton X, Mamdouh Z, Ghosh R, Du H, Kuriakose G, Beatini N, Grabowski GA, Maxfield FR, Tabas I. Buton X, et al. Among authors: beatini n. J Biol Chem. 1999 Nov 5;274(45):32112-21. doi: 10.1074/jbc.274.45.32112. J Biol Chem. 1999. PMID: 10542246 Free article.
11 results