Yergey JA - Search Results

1

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.

Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y. Delorme D, et al. Among authors: yergey ja. J Med Chem. 1996 Sep 27;39(20):3951-70. doi: 10.1021/jm960301c. J Med Chem. 1996. PMID: 8831761

2

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding.

Chauret N, Guay D, Li C, Day S, Silva J, Blouin M, Ducharme Y, Yergey JA, Nicoll-Griffith DA. Chauret N, et al. Among authors: yergey ja. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2149-52. doi: 10.1016/s0960-894x(02)00349-9. Bioorg Med Chem Lett. 2002. PMID: 12127525

3

In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539.

Chauret N, Li C, Ducharme Y, Trimble LA, Yergey JA, Ramachandran C, Nicoll-Griffith DA. Chauret N, et al. Among authors: yergey ja. Drug Metab Dispos. 1995 Jan;23(1):65-71. Drug Metab Dispos. 1995. PMID: 7720527

4

Integrated application of capillary HPLC/continuous-flow liquid secondary ion mass spectrometry to discovery stage metabolism studies.

Li C, Chauret N, Ducharme Y, Trimble LA, Nicoll-Griffith DA, Yergey JA. Li C, et al. Among authors: yergey ja. Anal Chem. 1995 Sep 1;67(17):2931-6. doi: 10.1021/ac00113a030. Anal Chem. 1995. PMID: 8779418

5

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

Nicoll-Griffith DA, Yergey JA, Trimble LA, Silva JM, Li C, Chauret N, Gauthier JY, Grimm E, Léger S, Roy P, Thérien M, Wang Z, Prasit P, Zamboni R, Young RN, Brideau C, Chan CC, Mancini J, Riendeau D. Nicoll-Griffith DA, et al. Among authors: yergey ja. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2683-6. doi: 10.1016/s0960-894x(00)00538-2. Bioorg Med Chem Lett. 2000. PMID: 11128651

6

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

Chauret N, Yergey JA, Brideau C, Friesen RW, Mancini J, Riendeau D, Silva J, Styhler A, Trimble LA, Nicoll-Griffith DA. Chauret N, et al. Among authors: yergey ja. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62. doi: 10.1016/s0960-894x(01)00135-4. Bioorg Med Chem Lett. 2001. PMID: 11327589

7

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.

Leblanc Y, Roy P, Wang Z, Li CS, Chauret N, Nicoll-Griffith DA, Silva JM, Aubin Y, Yergey JA, Chan CC, Riendeau D, Brideau C, Gordon R, Xu L, Webb J, Visco DM, Prasit P. Leblanc Y, et al. Among authors: yergey ja. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20. doi: 10.1016/s0960-894x(02)00739-4. Bioorg Med Chem Lett. 2002. PMID: 12392741

8

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor.

Nicoll-Griffith DA, Falgueyret JP, Silva JM, Morin PE, Trimble L, Chan CC, Clas S, Leger S, Wang Z, Yergey JA, Riendeau D. Nicoll-Griffith DA, et al. Among authors: yergey ja. Drug Metab Dispos. 1999 Mar;27(3):403-9. Drug Metab Dispos. 1999. PMID: 10064573

9

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization.

Li C, Chauret N, Trimble LA, Nicoll-Griffith DA, Silva JM, MacDonald D, Perrier H, Yergey JA, Parton T, Alexander RP, Warrellow GJ. Li C, et al. Among authors: yergey ja. Drug Metab Dispos. 2001 Mar;29(3):232-41. Drug Metab Dispos. 2001. PMID: 11181489

10

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Yergey JA, Trimble LA, Silva J, Chauret N, Li C, Therien M, Grimm E, Nicoll-Griffith DA. Yergey JA, et al. Drug Metab Dispos. 2001 May;29(5):638-44. Drug Metab Dispos. 2001. PMID: 11302928

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