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Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.
Gross CH, Parsons JD, Grossman TH, Charifson PS, Bellon S, Jernee J, Dwyer M, Chambers SP, Markland W, Botfield M, Raybuck SA. Gross CH, et al. Among authors: markland w. Antimicrob Agents Chemother. 2003 Mar;47(3):1037-46. doi: 10.1128/AAC.47.3.1037-1046.2003. Antimicrob Agents Chemother. 2003. PMID: 12604539 Free PMC article.
Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin.
Markland W, Ley AC, Ladner RC. Markland W, et al. Biochemistry. 1996 Jun 18;35(24):8058-67. doi: 10.1021/bi952629y. Biochemistry. 1996. PMID: 8672510
As discussed in the accompanying paper [Markland, W., Ley, A. C., & Ladner, R. C. (1996) Biochemistry 35, 8045-8057], we generated libraries from the first Kunitz domain of human lipoprotein-associated coagulation inhibitor (LACI-D1) using multivalent M13 III di …
As discussed in the accompanying paper [Markland, W., Ley, A. C., & Ladner, R. C. (1996) Biochemistry 35, 8045-8057], we g …
Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
Aronov AM, Tang Q, Martinez-Botella G, Bemis GW, Cao J, Chen G, Ewing NP, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Markland W, Namchuk MN, Nanthakumar S, Poondru S, Straub J, ter Haar E, Xie X. Aronov AM, et al. Among authors: markland w. J Med Chem. 2009 Oct 22;52(20):6362-8. doi: 10.1021/jm900630q. J Med Chem. 2009. PMID: 19827834
29 results