Park BK - Search Results

1

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Hawley SR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward SA. Hawley SR, et al. Among authors: park bk. Antimicrob Agents Chemother. 1996 Oct;40(10):2345-9. doi: 10.1128/AAC.40.10.2345. Antimicrob Agents Chemother. 1996. PMID: 8891142 Free PMC article.

2

The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: chemical mechanisms and the effects of fluorine substitution.

Tingle MD, Jewell H, Maggs JL, O'Neill PM, Park BK. Tingle MD, et al. Among authors: park bk. Biochem Pharmacol. 1995 Sep 28;50(7):1113-9. doi: 10.1016/0006-2952(95)00236-s. Biochem Pharmacol. 1995. PMID: 7575670

3

The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.

Ruscoe JE, Jewell H, Maggs JL, O'Neill PM, Storr RC, Ward SA, Park BK. Ruscoe JE, et al. Among authors: park bk. J Pharmacol Exp Ther. 1995 Apr;273(1):393-404. J Pharmacol Exp Ther. 1995. PMID: 7714794

4

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

O'Neill PM, Harrison AC, Storr RC, Hawley SR, Ward SA, Park BK. O'Neill PM, et al. Among authors: park bk. J Med Chem. 1994 Apr 29;37(9):1362-70. doi: 10.1021/jm00035a017. J Med Chem. 1994. PMID: 8176713

5

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

Hawley SR, Bray PG, O'Neill PM, Park BK, Ward SA. Hawley SR, et al. Among authors: park bk. Biochem Pharmacol. 1996 Sep 13;52(5):723-33. doi: 10.1016/0006-2952(96)00354-1. Biochem Pharmacol. 1996. PMID: 8765470

6

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.

Hawley SR, Bray PG, Park BK, Ward SA. Hawley SR, et al. Among authors: park bk. Mol Biochem Parasitol. 1996 Sep;80(1):15-25. doi: 10.1016/0166-6851(96)02655-2. Mol Biochem Parasitol. 1996. PMID: 8885219

7

Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design.

Naisbitt DJ, Ruscoe JE, Williams D, O'Neill PM, Pirmohamed M, Park BK. Naisbitt DJ, et al. Among authors: park bk. J Pharmacol Exp Ther. 1997 Feb;280(2):884-93. J Pharmacol Exp Ther. 1997. PMID: 9023303

8

Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.

O'Neill PM, Willock DJ, Hawley SR, Bray PG, Storr RC, Ward SA, Park BK. O'Neill PM, et al. Among authors: park bk. J Med Chem. 1997 Feb 14;40(4):437-48. doi: 10.1021/jm960370r. J Med Chem. 1997. PMID: 9046333

9

Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology.

Ruscoe JE, Tingle MD, O'Neill PM, Ward SA, Park BK. Ruscoe JE, et al. Among authors: park bk. Antimicrob Agents Chemother. 1998 Sep;42(9):2410-6. doi: 10.1128/AAC.42.9.2410. Antimicrob Agents Chemother. 1998. PMID: 9736572 Free PMC article.

10

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

Naisbitt DJ, Williams DP, O'Neill PM, Maggs JL, Willock DJ, Pirmohamed M, Park BK. Naisbitt DJ, et al. Among authors: park bk. Chem Res Toxicol. 1998 Dec;11(12):1586-95. doi: 10.1021/tx980148k. Chem Res Toxicol. 1998. PMID: 9860505

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