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The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.
Gotfryd K, Hansen M, Kawa A, Ellerbeck U, Nau H, Berezin V, Bock E, Walmod PS. Gotfryd K, et al. Among authors: ellerbeck u. Basic Clin Pharmacol Toxicol. 2011 Sep;109(3):164-74. doi: 10.1111/j.1742-7843.2011.00702.x. Epub 2011 Apr 18. Basic Clin Pharmacol Toxicol. 2011. PMID: 21439023 Free article.
Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency.
Bacon CL, Berezin V, Bode G, Bock E, Bojic U, Doherty P, Ehlers K, Ellerbeck U, Julien P, Kawa A, Maar TE, Nau H, Pirovano R, Regan CM, Schousboe A, Spezia F, Walsh FS, Williams EJ. Bacon CL, et al. Among authors: ellerbeck u. Toxicol In Vitro. 1998 Apr;12(2):101-9. doi: 10.1016/s0887-2333(97)00100-8. Toxicol In Vitro. 1998. PMID: 20654391