Nugiel DA - Search Results

1

An approach to the design of novel cognitive enhancers using molecular modeling and X-ray crystallography.

Nugiel DA, Voss ME, Brittelli DR, Calabrese JC. Nugiel DA, et al. Drug Des Discov. 1995 Apr;12(4):289-95. Drug Des Discov. 1995. PMID: 9040989

2

Synthesis of novel cyclic urea based HIV-1 protease inhibitors.

Nugiel DA, Reese K. Nugiel DA, et al. Drug Des Discov. 1995 Nov;13(2):83-7. Drug Des Discov. 1995. PMID: 8872453

3

Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.

Nugiel DA, Jacobs K, Cornelius L, Chang CH, Jadhav PK, Holler ER, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Logue KA, Gorey-Feret LJ, Lam GN, Erickson-Viitanen S, Seitz SP. Nugiel DA, et al. J Med Chem. 1997 May 9;40(10):1465-74. doi: 10.1021/jm960839i. J Med Chem. 1997. PMID: 9154969

4

Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.

Nugiel DA, Jacobs K, Kaltenbach RF, Worley T, Patel M, Meyer DT, Jadhav PK, De Lucca GV, Smyser TE, Klabe RM, Bacheler LT, Rayner MM, Seitz SP. Nugiel DA, et al. J Med Chem. 1996 May 24;39(11):2156-69. doi: 10.1021/jm960083n. J Med Chem. 1996. PMID: 8667359

5

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3(1,2).

Yue EW, Higley CA, DiMeo SV, Carini DJ, Nugiel DA, Benware C, Benfield PA, Burton CR, Cox S, Grafstrom RH, Sharp DM, Sisk LM, Boylan JF, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Seitz SP, Trainor GL. Yue EW, et al. Among authors: nugiel da. J Med Chem. 2002 Nov 21;45(24):5233-48. doi: 10.1021/jm0201722. J Med Chem. 2002. PMID: 12431051

6

The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.

Patel M, Kaltenbach RF 3rd, Nugiel DA, McHugh RJ Jr, Jadhav PK, Bacheler LT, Cordova BC, Klabe RM, Erickson-Viitanen S, Garber S, Reid C, Seitz SP. Patel M, et al. Among authors: nugiel da. Bioorg Med Chem Lett. 1998 May 5;8(9):1077-82. doi: 10.1016/s0960-894x(98)00175-9. Bioorg Med Chem Lett. 1998. PMID: 9871711

7

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.

Nugiel DA, Vidwans A, Etzkorn AM, Rossi KA, Benfield PA, Burton CR, Cox S, Doleniak D, Seitz SP. Nugiel DA, et al. J Med Chem. 2002 Nov 21;45(24):5224-32. doi: 10.1021/jm020171+. J Med Chem. 2002. PMID: 12431050

8

Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors.

Nugiel DA, Etzkorn AM, Vidwans A, Benfield PA, Boisclair M, Burton CR, Cox S, Czerniak PM, Doleniak D, Seitz SP. Nugiel DA, et al. J Med Chem. 2001 Apr 26;44(9):1334-6. doi: 10.1021/jm0100032. J Med Chem. 2001. PMID: 11311054 No abstract available.

9

Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.

Pavia MR, Lobbestael SJ, Nugiel D, Mayhugh DR, Gregor VE, Taylor CP, Schwarz RD, Brahce L, Vartanian MG. Pavia MR, et al. J Med Chem. 1992 Oct 30;35(22):4238-48. doi: 10.1021/jm00100a032. J Med Chem. 1992. PMID: 1433224

10

Stereoisomers of cyclic urea HIV-1 protease inhibitors: synthesis and binding affinities.

Kaltenbach RF 3rd, Nugiel DA, Lam PY, Klabe RM, Seitz SP. Kaltenbach RF 3rd, et al. Among authors: nugiel da. J Med Chem. 1998 Dec 3;41(25):5113-7. doi: 10.1021/jm980255b. J Med Chem. 1998. PMID: 9836627

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