Bishop WR - Search Results

1

Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase.

Njoroge FG, Doll RJ, Vibulbhan B, Alvarez CS, Bishop WR, Petrin J, Kirschmeier P, Carruthers NI, Wong JK, Albanese MM, Piwinski JJ, Catino J, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. Among authors: bishop wr. Bioorg Med Chem. 1997 Jan;5(1):101-13. doi: 10.1016/s0968-0896(96)00206-4. Bioorg Med Chem. 1997. PMID: 9043662

2

Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.

Cooper AB, Strickland CL, Wang J, Desai J, Kirschmeier P, Patton R, Bishop WR, Weber PC, Girijavallabhan V. Cooper AB, et al. Among authors: bishop wr. Bioorg Med Chem Lett. 2002 Feb 25;12(4):601-5. doi: 10.1016/s0960-894x(01)00826-5. Bioorg Med Chem Lett. 2002. PMID: 11844681

3

Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase.

Njoroge FG, Vibulbhan B, Pinto P, Strickland CL, Bishop WR, Kirschmeir P, Girijavallabhan V, Ganguly AK. Njoroge FG, et al. Among authors: bishop wr. Bioorg Med Chem. 2003 Jan 2;11(1):139-43. doi: 10.1016/s0968-0896(02)00308-5. Bioorg Med Chem. 2003. PMID: 12467716

4

Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding.

Njoroge FG, Vibulbhan B, Pinto P, Strickland C, Kirschmeier P, Bishop WR, Girijavallabhan V. Njoroge FG, et al. Among authors: bishop wr. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5877-80. doi: 10.1016/j.bmcl.2004.09.026. Bioorg Med Chem Lett. 2004. PMID: 15501060

5

Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.

Njoroge FG, Vibulbhan B, Pinto P, Strickland C, Bishop WR, Nomeir A, Girijavallabhan V. Njoroge FG, et al. Among authors: bishop wr. Bioorg Med Chem Lett. 2006 Feb 15;16(4):984-8. doi: 10.1016/j.bmcl.2005.10.090. Epub 2005 Nov 16. Bioorg Med Chem Lett. 2006. PMID: 16298128

6

Discovery of C-imidazole azaheptapyridine FPT inhibitors.

Zhu HY, Cooper AB, Desai J, Njoroge G, Kirschmeier P, Bishop WR, Strickland C, Hruza A, Doll RJ, Girijavallabhan VM. Zhu HY, et al. Among authors: bishop wr. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1134-6. doi: 10.1016/j.bmcl.2009.12.013. Epub 2009 Dec 6. Bioorg Med Chem Lett. 2010. PMID: 20056542

7

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells.

Bishop WR, Bond R, Petrin J, Wang L, Patton R, Doll R, Njoroge G, Catino J, Schwartz J, Windsor W, et al. Bishop WR, et al. J Biol Chem. 1995 Dec 22;270(51):30611-8. doi: 10.1074/jbc.270.51.30611. J Biol Chem. 1995. PMID: 8530497 Free article.

8

Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation.

Mallams AK, Njoroge FG, Doll RJ, Snow ME, Kaminski JJ, Rossman RR, Vibulbhan B, Bishop WR, Kirschmeier P, Liu M, Bryant MS, Alvarez C, Carr D, James L, King I, Li Z, Lin CC, Nardo C, Petrin J, Remiszewski SW, Taveras AG, Wang S, Wong J, Catino J, Ganguly AK, et al. Mallams AK, et al. Among authors: bishop wr. Bioorg Med Chem. 1997 Jan;5(1):93-9. doi: 10.1016/s0968-0896(96)00205-2. Bioorg Med Chem. 1997. PMID: 9043661

9

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I.

Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L, Patton R, Windsor WT, Syto R, Zhang R, Bishop WR. Zhang FL, et al. Among authors: bishop wr. J Biol Chem. 1997 Apr 11;272(15):10232-9. doi: 10.1074/jbc.272.15.10232. J Biol Chem. 1997. PMID: 9092572 Free article.

10

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors.

Whyte DB, Kirschmeier P, Hockenberry TN, Nunez-Oliva I, James L, Catino JJ, Bishop WR, Pai JK. Whyte DB, et al. Among authors: bishop wr. J Biol Chem. 1997 May 30;272(22):14459-64. doi: 10.1074/jbc.272.22.14459. J Biol Chem. 1997. PMID: 9162087 Free article.

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