Doherty AM - Search Results

1

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM. Patt WC, et al. Among authors: doherty am. J Med Chem. 1997 Mar 28;40(7):1063-74. doi: 10.1021/jm9606507. J Med Chem. 1997. PMID: 9089328

2

Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).

Massa MA, Patt WC, Ahn K, Sisneros AM, Herman SB, Doherty A. Massa MA, et al. Among authors: doherty a. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2117-22. doi: 10.1016/s0960-894x(98)00375-8. Bioorg Med Chem Lett. 1998. PMID: 9873497

3

Design of a functional hexapeptide antagonist of endothelin.

Cody WL, Doherty AM, He JX, DePue PL, Rapundalo ST, Hingorani GA, Major TC, Panek RL, Dudley DT, Haleen SJ, et al. Cody WL, et al. Among authors: doherty am. J Med Chem. 1992 Aug 21;35(17):3301-3. doi: 10.1021/jm00095a029. J Med Chem. 1992. PMID: 1324321 No abstract available.

4

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: doherty am. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

5

In vitro and in vivo studies with a series of hexapeptide endothelin antagonists.

Doherty AM, Cody WL, He JX, DePue PL, Cheng XM, Welch KM, Flynn MA, Reynolds EE, LaDouceur DM, Davis LS, et al. Doherty AM, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S98-102. doi: 10.1097/00005344-199322008-00027. J Cardiovasc Pharmacol. 1993. PMID: 7510009

6

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: doherty am. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

7

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al. Doherty AM, et al. J Med Chem. 1995 Apr 14;38(8):1259-63. doi: 10.1021/jm00008a002. J Med Chem. 1995. PMID: 7731010 No abstract available.

8

Effects of selective endothelin antagonists on the hemodynamic response to cyclosporin A.

Davis LS, Haleen SJ, Doherty AM, Cody WL, Keiser JA. Davis LS, et al. Among authors: doherty am. J Am Soc Nephrol. 1994 Jan;4(7):1448-54. doi: 10.1681/ASN.V471448. J Am Soc Nephrol. 1994. PMID: 8161726

9

Structure-activity relationships of a novel series of orally active nonpeptide ETA and ETA/B endothelin receptor-selective antagonists.

Doherty AM, Patt WC, Repine J, Edmunds JJ, Berryman KA, Reisdorph BR, Walker DM, Haleen SJ, Keiser JA, Flynn MA, et al. Doherty AM, et al. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S358-61. J Cardiovasc Pharmacol. 1995. PMID: 8587414

10

Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.

Cody WL, He JX, Reily MD, Haleen SJ, Walker DM, Reyner EL, Stewart BH, Doherty AM. Cody WL, et al. Among authors: doherty am. J Med Chem. 1997 Jul 4;40(14):2228-40. doi: 10.1021/jm970161m. J Med Chem. 1997. PMID: 9216842

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