Kowalski TJ - Search Results

1

Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model.

Raychaudhuri A, Chertock H, Chovan J, Jones LS, Kimble EF, Kowalski TJ, Peppard J, White DH, Satoh Y, Roland D. Raychaudhuri A, et al. Among authors: kowalski tj. Naunyn Schmiedebergs Arch Pharmacol. 1997 Apr;355(4):470-4. doi: 10.1007/pl00004971. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9109363

2

Leukotriene biosynthesis inhibition by aryl and aroyl substituted naphthoquinones.

Roland DM, Macchia WM, Grim KS, Kimble EF, White DH, Kowalski TJ. Roland DM, et al. Among authors: kowalski tj. Agents Actions. 1991 Sep;34(1-2):145-7. doi: 10.1007/BF01993262. Agents Actions. 1991. PMID: 1665288

3

Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.

Satoh Y, Stanton JL, Hutchison AJ, Libby AH, Kowalski TJ, Lee WH, White DH, Kimble EF. Satoh Y, et al. Among authors: kowalski tj. J Med Chem. 1993 Nov 12;36(23):3580-94. doi: 10.1021/jm00075a013. J Med Chem. 1993. PMID: 8246226

4

CGS 22745: a selective orally active inhibitor of 5-lipoxygenase.

Kimble E, Kowalski T, White D, Raychauduri A, Pastor G, Chertock H, Lee W, Neale R, Hamdan A, Wasley J. Kimble E, et al. Agents Actions. 1991 Sep;34(1-2):125-8. doi: 10.1007/BF01993256. Agents Actions. 1991. PMID: 1665286

5

Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors.

Satoh Y, Powers C, Toledo LM, Kowalski TJ, Peters PA, Kimble EF. Satoh Y, et al. Among authors: kowalski tj. J Med Chem. 1995 Jan 6;38(1):68-75. doi: 10.1021/jm00001a012. J Med Chem. 1995. PMID: 7837242

6

CGS 26529: the biological profile of a novel, orally active 5-lipoxygenase inhibitor with an extended duration of action.

Kimble E, Kowalski T, Peters P, Lee W, Koehler J, Raychaudhuri A, Chertock H, Blancuzzi V, van Duzer J. Kimble E, et al. Inflamm Res. 1995 Aug;44 Suppl 2:S147-8. doi: 10.1007/BF01778305. Inflamm Res. 1995. PMID: 8548371 No abstract available.

7

Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.

Kowalski TJ, Farley C, Cohen-Williams ME, Varty G, Spar BD. Kowalski TJ, et al. Eur J Pharmacol. 2004 Aug 16;497(1):41-7. doi: 10.1016/j.ejphar.2004.06.027. Eur J Pharmacol. 2004. PMID: 15321733

8

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. Among authors: kowalski tj. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

9

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: kowalski tj. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

10

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: kowalski tj. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926

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