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Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
Imai M, Shiota T, Kataoka K, Tarby CM, Moree WJ, Tsutsumi T, Sudo M, Ramirez-Weinhouse MM, Comer D, Sun CM, Yamagami S, Tanaka H, Morita T, Hada T, Greene J, Barnum D, Saunders J, Myers PL, Kato Y, Endo N. Imai M, et al. Among authors: endo n. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5407-11. doi: 10.1016/j.bmcl.2004.08.008. Bioorg Med Chem Lett. 2004. PMID: 15454235
Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Tsutsumi T, Sudo M, Endo N, Muroga Y, Hada T, Fanning D, Saunders J, Kato Y, Myers PL, Tarby CM. Moree WJ, et al. Among authors: endo n. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73. doi: 10.1016/j.bmcl.2008.02.015. Epub 2008 Feb 10. Bioorg Med Chem Lett. 2008. PMID: 18313297
Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Sudo M, Tsutsumi T, Endo N, Muroga Y, Hada T, Tanaka H, Morita T, Greene J, Barnum D, Saunders J, Kato Y, Myers PL, Tarby CM. Moree WJ, et al. Among authors: endo n. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5413-6. doi: 10.1016/j.bmcl.2004.08.009. Bioorg Med Chem Lett. 2004. PMID: 15454236
1,255 results