Hermsen HP - Search Results

1

Mutational analysis of the putative devazepide binding site of the CCK(A) receptor.

Smeets RL, IJzerman AP, Hermsen HP, Ophorst OJ, Van Emst-de Vries SE, De Pont JJ, Willems PH. Smeets RL, et al. Among authors: hermsen hp. Eur J Pharmacol. 1997 Apr 23;325(1):93-9. doi: 10.1016/s0014-2999(97)00106-4. Eur J Pharmacol. 1997. PMID: 9151944 Free article.

2

Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820.

Swarts HG, Hermsen HP, Koenderink JB, Willems PH, de Pont JJ. Swarts HG, et al. Among authors: hermsen hp. Mol Pharmacol. 1999 Mar;55(3):541-7. Mol Pharmacol. 1999. PMID: 10051539

3

Mutation of aspartate 804 of Na(+),K(+)-ATPase modifies the cation binding pocket and thereby generates a high Na(+)-ATPase activity.

Koenderink JB, Swarts HG, Hermsen HP, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: hermsen hp. Biochemistry. 2000 Aug 15;39(32):9959-66. doi: 10.1021/bi0001168. Biochemistry. 2000. PMID: 10933816

4

High-affinity ouabain binding by a chimeric gastric H+,K+-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the alpha 1-subunit of rat Na+,K+-ATPase.

Koenderink JB, Hermsen HP, Swarts HG, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: hermsen hp. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11209-14. doi: 10.1073/pnas.200109597. Proc Natl Acad Sci U S A. 2000. PMID: 11016952 Free PMC article.

5

The negative charge of glutamic acid-820 in the gastric H+,K+-ATPase alpha-subunit is essential for K+ activation of the enzyme activity.

Hermsen HP, Swarts HG, Koenderink JB, De Pont JJ. Hermsen HP, et al. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):465-72. doi: 10.1042/bj3310465. Biochem J. 1998. PMID: 9531486 Free PMC article.

6

Constitutive activation of gastric H+,K+-ATPase by a single mutation.

Swarts HG, Hermsen HP, Koenderink JB, Schuurmans Stekhoven FM, De Pont JJ. Swarts HG, et al. Among authors: hermsen hp. EMBO J. 1998 Jun 1;17(11):3029-35. doi: 10.1093/emboj/17.11.3029. EMBO J. 1998. PMID: 9606185 Free PMC article.

7

Mutagenesis of glutamate 820 of the gastric H+,K+-ATPase alpha-subunit to aspartate decreases the apparent ATP affinity.

Hermsen HP, Swarts HG, Koenderink JB, De Pont JJ. Hermsen HP, et al. Biochim Biophys Acta. 1999 Jan 12;1416(1-2):251-7. doi: 10.1016/s0005-2736(98)00227-2. Biochim Biophys Acta. 1999. PMID: 9889380 Free article.

8

The beta-subunits of Na+,K+-ATPase and gastric H+,K+-ATPase have a high preference for their own alpha-subunit and affect the K+ affinity of these enzymes.

Koenderink JB, Swarts HG, Hermsen HP, De Pont JJ. Koenderink JB, et al. Among authors: hermsen hp. J Biol Chem. 1999 Apr 23;274(17):11604-10. doi: 10.1074/jbc.274.17.11604. J Biol Chem. 1999. PMID: 10206969 Free article.

9

The carbonyl group of glutamic acid-795 is essential for gastric H+,K+-ATPase activity.

Hermsen HP, Koenderink JB, Swarts HG, De Pont JJ. Hermsen HP, et al. Biochemistry. 2000 Feb 15;39(6):1330-7. doi: 10.1021/bi991396y. Biochemistry. 2000. PMID: 10684613

10

Chimeras of X+, K+-ATPases. The M1-M6 region of Na+, K+-ATPase is required for Na+-activated ATPase activity, whereas the M7-M10 region of H+, K+-ATPase is involved in K+ de-occlusion.

Koenderink JB, Swarts HG, Stronks HC, Hermsen HP, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: hermsen hp. J Biol Chem. 2001 Apr 13;276(15):11705-11. doi: 10.1074/jbc.M010804200. Epub 2001 Jan 16. J Biol Chem. 2001. PMID: 11278751 Free article.

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