Shimomura I - Search Results

1

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Shimano H, et al. Among authors: shimomura i. J Clin Invest. 1997 Oct 15;100(8):2115-24. doi: 10.1172/JCI119746. J Clin Invest. 1997. PMID: 9329978 Free PMC article.

2

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.

Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Shimomura I, et al. Mol Cell. 2000 Jul;6(1):77-86. Mol Cell. 2000. PMID: 10949029 Free article.

3

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Repa JJ, et al. Among authors: shimomura i. Genes Dev. 2000 Nov 15;14(22):2819-30. doi: 10.1101/gad.844900. Genes Dev. 2000. PMID: 11090130 Free PMC article.

4

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I. Matsuda M, et al. Among authors: shimomura i. Genes Dev. 2001 May 15;15(10):1206-16. doi: 10.1101/gad.891301. Genes Dev. 2001. PMID: 11358865 Free PMC article.

5

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Shimano H, et al. Among authors: shimomura i. J Clin Invest. 1996 Oct 1;98(7):1575-84. doi: 10.1172/JCI118951. J Clin Invest. 1996. PMID: 8833906 Free PMC article.

6

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Shimomura I, et al. J Clin Invest. 1997 Mar 1;99(5):838-45. doi: 10.1172/JCI119247. J Clin Invest. 1997. PMID: 9062340 Free PMC article.

7

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Shimano H, et al. Among authors: shimomura i. J Clin Invest. 1997 Mar 1;99(5):846-54. doi: 10.1172/JCI119248. J Clin Invest. 1997. PMID: 9062341 Free PMC article.

8

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.

Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, Brown MS. Shimomura I, et al. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12354-9. doi: 10.1073/pnas.94.23.12354. Proc Natl Acad Sci U S A. 1997. PMID: 9356453 Free PMC article.

9

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.

Horton JD, Bashmakov Y, Shimomura I, Shimano H. Horton JD, et al. Among authors: shimomura i. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5987-92. doi: 10.1073/pnas.95.11.5987. Proc Natl Acad Sci U S A. 1998. PMID: 9600904 Free PMC article.

10

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Horton JD, et al. Among authors: shimomura i. J Clin Invest. 1998 Jun 1;101(11):2331-9. doi: 10.1172/JCI2961. J Clin Invest. 1998. PMID: 9616204 Free PMC article.

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