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Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Moore RC, et al. Among authors: strome r. J Mol Biol. 1999 Oct 1;292(4):797-817. doi: 10.1006/jmbi.1999.3108. J Mol Biol. 1999. PMID: 10525406
LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.
Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G. Ehsani S, et al. Among authors: strome r. J Mol Biol. 2012 Sep 28;422(4):556-574. doi: 10.1016/j.jmb.2012.06.003. Epub 2012 Jun 9. J Mol Biol. 2012. PMID: 22687393 Free PMC article.
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D. Chishti MA, et al. Among authors: strome r. J Biol Chem. 2001 Jun 15;276(24):21562-70. doi: 10.1074/jbc.M100710200. Epub 2001 Mar 15. J Biol Chem. 2001. PMID: 11279122 Free article.
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Citron M, et al. Among authors: strome r. Nat Med. 1997 Jan;3(1):67-72. doi: 10.1038/nm0197-67. Nat Med. 1997. PMID: 8986743
The cellular prion protein binds copper in vivo.
Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D, Kretzschmar H. Brown DR, et al. Among authors: strome r. Nature. 1997 Dec 18-25;390(6661):684-7. doi: 10.1038/37783. Nature. 1997. PMID: 9414160
A novel double mutation in FUS gene causing sporadic ALS.
Robertson J, Bilbao J, Zinman L, Hazrati LN, Tokuhiro S, Sato C, Moreno D, Strome R, Mackenzie IR, Rogaeva E. Robertson J, et al. Among authors: strome r. Neurobiol Aging. 2011 Mar;32(3):553.e27-30. doi: 10.1016/j.neurobiolaging.2010.05.015. Epub 2010 Jun 18. Neurobiol Aging. 2011. PMID: 20561714
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