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Page 1
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
Veale CA, Bernstein PR, Bohnert CM, Brown FJ, Bryant C, Damewood JR Jr, Earley R, Feeney SW, Edwards PD, Gomes B, Hulsizer JM, Kosmider BJ, Krell RD, Moore G, Salcedo TW, Shaw A, Silberstein DS, Steelman GB, Stein M, Strimpler A, Thomas RM, Vacek EP, Williams JC, Wolanin DJ, Woolson S. Veale CA, et al. Among authors: bernstein pr. J Med Chem. 1997 Sep 26;40(20):3173-81. doi: 10.1021/jm970250z. J Med Chem. 1997. PMID: 9379436
Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
Bernstein PR, Andisik D, Bradley PK, Bryant CB, Ceccarelli C, Damewood JR Jr, Earley R, Edwards PD, Feeney S, Gomes BC, et al. Bernstein PR, et al. J Med Chem. 1994 Sep 30;37(20):3313-26. doi: 10.1021/jm00046a016. J Med Chem. 1994. PMID: 7932559
Inhibitors of human leukocyte elastase.
Bernstein PR, Edwards PD, Williams JC. Bernstein PR, et al. Prog Med Chem. 1994;31:59-120. doi: 10.1016/s0079-6468(08)70019-5. Prog Med Chem. 1994. PMID: 8029481 Review. No abstract available.
Design of orally active, non-peptidic inhibitors of human leukocyte elastase.
Brown FJ, Andisik DW, Bernstein PR, Bryant CB, Ceccarelli C, Damewood JR Jr, Edwards PD, Earley RA, Feeney S, Green RC, et al. Brown FJ, et al. Among authors: bernstein pr. J Med Chem. 1994 Apr 29;37(9):1259-61. doi: 10.1021/jm00035a004. J Med Chem. 1994. PMID: 8176703 No abstract available.
Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orally active antagonist of leukotrienes D4 and E4.
Jacobs RT, Bernstein PR, Cronk LA, Vacek EP, Newcomb LF, Aharony D, Buckner CK, Kusner EJ. Jacobs RT, et al. Among authors: bernstein pr. J Med Chem. 1994 Apr 29;37(9):1282-97. doi: 10.1021/jm00035a008. J Med Chem. 1994. PMID: 8176706
46 results