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Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
J Med Chem. 1997 Sep 26;40(20):3173-81. doi: 10.1021/jm970250z.
J Med Chem. 1997.
PMID: 9379436
Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK₁/NK₃ antagonists.
Bissantz C, Bohnert C, Hoffmann T, Marcuz A, Schnider P, Malherbe P.
Bissantz C, et al.
J Med Chem. 2012 Jun 14;55(11):5061-76. doi: 10.1021/jm2017072. Epub 2012 May 22.
J Med Chem. 2012.
PMID: 22574973
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Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.
Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, Ratni H, Spooren W, Ballard TM, Bissantz C.
Malherbe P, et al.
Neuropharmacology. 2014 Nov;86:259-72. doi: 10.1016/j.neuropharm.2014.07.017. Epub 2014 Aug 5.
Neuropharmacology. 2014.
PMID: 25107588
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Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.
Flohr A, Hutter R, Mueller B, Bohnert C, Pellisson M, Schaffhauser H.
Flohr A, et al.
Bioorg Med Chem Lett. 2017 Dec 15;27(24):5415-5419. doi: 10.1016/j.bmcl.2017.11.008. Epub 2017 Nov 6.
Bioorg Med Chem Lett. 2017.
PMID: 29146472
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