Sharples CG - Search Results

1

Pharmacology of nicotinic acetylcholine receptor (nAChR) upregulation in the transfected cell line, M10.

Whiteaker P, Sharples CG, Wonnacott S. Whiteaker P, et al. Among authors: sharples cg. Biochem Soc Trans. 1997 Aug;25(3):550S. doi: 10.1042/bst025550s. Biochem Soc Trans. 1997. PMID: 9388764 No abstract available.

2

Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

Whiteaker P, Sharples CG, Wonnacott S. Whiteaker P, et al. Among authors: sharples cg. Mol Pharmacol. 1998 May;53(5):950-62. Mol Pharmacol. 1998. PMID: 9584223

3

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T. Sharples CG, et al. J Med Chem. 2002 Jul 18;45(15):3235-45. doi: 10.1021/jm020814l. J Med Chem. 2002. PMID: 12109907

4

UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.

Sharples CG, Kaiser S, Soliakov L, Marks MJ, Collins AC, Washburn M, Wright E, Spencer JA, Gallagher T, Whiteaker P, Wonnacott S. Sharples CG, et al. J Neurosci. 2000 Apr 15;20(8):2783-91. doi: 10.1523/JNEUROSCI.20-08-02783.2000. J Neurosci. 2000. PMID: 10751429 Free PMC article.

5

Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165.

Sutherland A, Gallagher T, Sharples CG, Wonnacott S. Sutherland A, et al. Among authors: sharples cg. J Org Chem. 2003 Mar 21;68(6):2475-8. doi: 10.1021/jo026698b. J Org Chem. 2003. PMID: 12636420

6

Attentional effects of nicotinic agonists in rats.

Hahn B, Sharples CG, Wonnacott S, Shoaib M, Stolerman IP. Hahn B, et al. Among authors: sharples cg. Neuropharmacology. 2003 Jun;44(8):1054-67. doi: 10.1016/s0028-3908(03)00099-6. Neuropharmacology. 2003. PMID: 12763099

7

Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380.

Mogg AJ, Jones FA, Pullar IA, Sharples CG, Wonnacott S. Mogg AJ, et al. Among authors: sharples cg. Neuropharmacology. 2004 Nov;47(6):848-59. doi: 10.1016/j.neuropharm.2004.06.013. Neuropharmacology. 2004. PMID: 15527819

8

Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.

Karig G, Large JM, Sharples CG, Sutherland A, Gallagher T, Wonnacott S. Karig G, et al. Among authors: sharples cg. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2825-8. doi: 10.1016/s0960-894x(03)00594-8. Bioorg Med Chem Lett. 2003. PMID: 14611837

9

Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.

Schmitt JD, Sharples CG, Caldwell WS. Schmitt JD, et al. Among authors: sharples cg. J Med Chem. 1999 Aug 12;42(16):3066-74. doi: 10.1021/jm990093z. J Med Chem. 1999. PMID: 10447950

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