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A randomized, blinded, comparative trial of one pepsin-digested and two whole IgG antivenoms for Bothrops snake bites in Uraba, Colombia. The Regional Group on Antivenom Therapy Research (REGATHER).
Otero-Patiño R, Cardoso JL, Higashi HG, Nunez V, Diaz A, Toro MF, Garcia ME, Sierra A, Garcia LF, Moreno AM, Medina MC, Castañeda N, Silva-Diaz JF, Murcia M, Cardenas SY, Dias da Silva WD. Otero-Patiño R, et al. Am J Trop Med Hyg. 1998 Feb;58(2):183-9. doi: 10.4269/ajtmh.1998.58.183. Am J Trop Med Hyg. 1998. PMID: 9580075 Clinical Trial.
Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.
Otero-Patiño R, Segura A, Herrera M, Angulo Y, León G, Gutiérrez JM, Barona J, Estrada S, Pereañez A, Quintana JC, Vargas LJ, Gómez JP, Díaz A, Suárez AM, Fernández J, Ramírez P, Fabra P, Perea M, Fernández D, Arroyo Y, Betancur D, Pupo L, Córdoba EA, Ramírez CE, Arrieta AB, Rivero A, Mosquera DC, Conrado NL, Ortiz R. Otero-Patiño R, et al. Toxicon. 2012 Feb;59(2):344-55. doi: 10.1016/j.toxicon.2011.11.017. Epub 2011 Nov 29. Toxicon. 2012. PMID: 22146491 Clinical Trial.
Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom.
Vélez SM, Salazar M, Acosta de Patiño H, Gómez L, Rodriguez A, Correa D, Saldaña J, Navarro D, Lomonte B, Otero-Patiño R, Gutiérrez JM. Vélez SM, et al. Among authors: otero patino r. Toxicon. 2017 Jun 15;132:55-61. doi: 10.1016/j.toxicon.2017.04.002. Epub 2017 Apr 7. Toxicon. 2017. PMID: 28392273