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Actions of A-131701, a novel, selective antagonist for alpha-1A compared with alpha-1B adrenoceptors on intraurethral and blood pressure responses in conscious dogs and a pharmacodynamic assessment of in vivo prostatic selectivity.
Hancock AA, Brune ME, Witte DG, Marsh KC, Katwala S, Milicic I, Ireland LM, Crowell D, Meyer MD, Kerwin JF Jr. Hancock AA, et al. Among authors: meyer md. J Pharmacol Exp Ther. 1998 May;285(2):628-42. J Pharmacol Exp Ther. 1998. PMID: 9580607
Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists.
Witte DG, Brune ME, Katwala SP, Milicic I, Stolarik D, Hui YH, Marsh KC, Kerwin JF Jr, Meyer MD, Hancock AA. Witte DG, et al. Among authors: meyer md. J Pharmacol Exp Ther. 2002 Feb;300(2):495-504. doi: 10.1124/jpet.300.2.495. J Pharmacol Exp Ther. 2002. PMID: 11805209
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH).
Meyer MD, Altenbach RJ, Basha FZ, Carroll WA, Condon S, Elmore SW, Kerwin JF Jr, Sippy KB, Tietje K, Wendt MD, Hancock AA, Brune ME, Buckner SA, Drizin I. Meyer MD, et al. J Med Chem. 2000 Apr 20;43(8):1586-603. doi: 10.1021/jm990567u. J Med Chem. 2000. PMID: 10780916
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.
Altenbach RJ, Khilevich A, Meyer MD, Buckner SA, Milicic I, Daza AV, Brune ME, O'Neill AB, Gauvin DM, Cain JC, Nakane M, Holladay MW, Williams M, Brioni JD, Sullivan JP. Altenbach RJ, et al. Among authors: meyer md. J Med Chem. 2002 Sep 26;45(20):4395-7. doi: 10.1021/jm025550h. J Med Chem. 2002. PMID: 12238918
125 results