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Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue.
Rivara S, Diamantini G, Di Giacomo B, Lamba D, Gatti G, Lucini V, Pannacci M, Mor M, Spadoni G, Tarzia G. Rivara S, et al. Among authors: di giacomo b. Bioorg Med Chem. 2006 May 15;14(10):3383-91. doi: 10.1016/j.bmc.2005.12.053. Epub 2006 Jan 20. Bioorg Med Chem. 2006. PMID: 16431121
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study.
Spadoni G, Balsamini C, Diamantini G, Di Giacomo B, Tarzia G, Mor M, Plazzi PV, Rivara S, Lucini V, Nonno R, Pannacci M, Fraschini F, Stankov BM. Spadoni G, et al. Among authors: di giacomo b. J Med Chem. 1997 Jun 20;40(13):1990-2002. doi: 10.1021/jm960651z. J Med Chem. 1997. PMID: 9207940
52 results