Knox JR - Search Results

1

Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.

Lin S, Thomas M, Shlaes DM, Rudin SD, Knox JR, Anderson V, Bonomo RA. Lin S, et al. Among authors: knox jr. Biochem J. 1998 Jul 15;333 ( Pt 2)(Pt 2):395-400. doi: 10.1042/bj3330395. Biochem J. 1998. PMID: 9735103 Free PMC article.

2

Complementary roles of mutations at positions 69 and 242 in a class A beta-lactamase.

Bonomo RA, Dawes CG, Knox JR, Shlaes DM. Bonomo RA, et al. Among authors: knox jr. Biochim Biophys Acta. 1995 Feb 22;1247(1):113-20. doi: 10.1016/0167-4838(94)00187-l. Biochim Biophys Acta. 1995. PMID: 7873579

3

beta-Lactamase mutations far from the active site influence inhibitor binding.

Bonomo RA, Dawes CG, Knox JR, Shlaes DM. Bonomo RA, et al. Among authors: knox jr. Biochim Biophys Acta. 1995 Feb 22;1247(1):121-5. doi: 10.1016/0167-4838(94)00188-m. Biochim Biophys Acta. 1995. PMID: 7873581

4

Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.

Bonomo RA, Knox JR, Rudin SD, Shlaes DM. Bonomo RA, et al. Among authors: knox jr. Antimicrob Agents Chemother. 1997 Sep;41(9):1940-3. doi: 10.1128/AAC.41.9.1940. Antimicrob Agents Chemother. 1997. PMID: 9303389 Free PMC article.

5

Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant.

Sun T, Bethel CR, Bonomo RA, Knox JR. Sun T, et al. Among authors: knox jr. Biochemistry. 2004 Nov 9;43(44):14111-7. doi: 10.1021/bi0487903. Biochemistry. 2004. PMID: 15518561

6

Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1.

Nukaga M, Bethel CR, Thomson JM, Hujer AM, Distler A, Anderson VE, Knox JR, Bonomo RA. Nukaga M, et al. Among authors: knox jr. J Am Chem Soc. 2008 Sep 24;130(38):12656-62. doi: 10.1021/ja7111146. Epub 2008 Aug 30. J Am Chem Soc. 2008. PMID: 18761444 Free PMC article.

7

Structure of the SHV-1 beta-lactamase.

Kuzin AP, Nukaga M, Nukaga Y, Hujer AM, Bonomo RA, Knox JR. Kuzin AP, et al. Among authors: knox jr. Biochemistry. 1999 May 4;38(18):5720-7. doi: 10.1021/bi990136d. Biochemistry. 1999. PMID: 10231522

8

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam.

Kuzin AP, Nukaga M, Nukaga Y, Hujer A, Bonomo RA, Knox JR. Kuzin AP, et al. Among authors: knox jr. Biochemistry. 2001 Feb 13;40(6):1861-6. doi: 10.1021/bi0022745. Biochemistry. 2001. PMID: 11327849

9

Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme.

Nukaga M, Mayama K, Hujer AM, Bonomo RA, Knox JR. Nukaga M, et al. Among authors: knox jr. J Mol Biol. 2003 Apr 18;328(1):289-301. doi: 10.1016/s0022-2836(03)00210-9. J Mol Biol. 2003. PMID: 12684014

10

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS. Venkatesan AM, et al. Among authors: knox jr. J Med Chem. 2006 Jul 27;49(15):4623-37. doi: 10.1021/jm060021p. J Med Chem. 2006. PMID: 16854068

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