Griffin RJ - Search Results

1

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.

Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Bowman KJ, et al. Among authors: griffin rj. Br J Cancer. 1998 Nov;78(10):1269-77. doi: 10.1038/bjc.1998.670. Br J Cancer. 1998. PMID: 9823965 Free PMC article.

2

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

White AW, Curtin NJ, Eastman BW, Golding BT, Hostomsky Z, Kyle S, Li J, Maegley KA, Skalitzky DJ, Webber SE, Yu XH, Griffin RJ. White AW, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2004 May 17;14(10):2433-7. doi: 10.1016/j.bmcl.2004.03.017. Bioorg Med Chem Lett. 2004. PMID: 15109627

3

Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092

4

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.

Curtin NJ, Bowman KJ, Turner RN, Huang B, Loughlin PJ, Calvert AH, Golding BT, Griffin RJ, Newell DR. Curtin NJ, et al. Among authors: griffin rj. Br J Cancer. 1999 Aug;80(11):1738-46. doi: 10.1038/sj.bjc.6690591. Br J Cancer. 1999. PMID: 10468290 Free PMC article.

5

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

Griffin RJ, Arris CE, Bleasdale C, Boyle FT, Calvert AH, Curtin NJ, Dalby C, Kanugula S, Lembicz NK, Newell DR, Pegg AE, Golding BT. Griffin RJ, et al. J Med Chem. 2000 Nov 2;43(22):4071-83. doi: 10.1021/jm000961o. J Med Chem. 2000. PMID: 11063604

6

Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.

White AW, Almassy R, Calvert AH, Curtin NJ, Griffin RJ, Hostomsky Z, Maegley K, Newell DR, Srinivasan S, Golding BT. White AW, et al. Among authors: griffin rj. J Med Chem. 2000 Nov 2;43(22):4084-97. doi: 10.1021/jm000950v. J Med Chem. 2000. PMID: 11063605

7

In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity.

Smith PG, Thomas HD, Barlow HC, Griffin RJ, Golding BT, Calvert AH, Newell DR, Curtin NJ. Smith PG, et al. Among authors: griffin rj. Clin Cancer Res. 2001 Jul;7(7):2105-13. Clin Cancer Res. 2001. PMID: 11448930

8

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors.

Boulton S, Pemberton LC, Porteous JK, Curtin NJ, Griffin RJ, Golding BT, Durkacz BW. Boulton S, et al. Among authors: griffin rj. Br J Cancer. 1995 Oct;72(4):849-56. doi: 10.1038/bjc.1995.423. Br J Cancer. 1995. PMID: 7547230 Free PMC article.

9

Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).

Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al. Griffin RJ, et al. Anticancer Drug Des. 1995 Sep;10(6):507-14. Anticancer Drug Des. 1995. PMID: 7575991 No abstract available.

10

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.

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