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Constrained corticotropin-releasing factor (CRF) agonists and antagonists with i-(i+3) Glu-Xaa-DXbb-Lys bridges.
Koerber SC, Gulyas J, Lahrichi SL, Corrigan A, Craig AG, Rivier C, Vale W, Rivier J. Koerber SC, et al. Among authors: rivier j, rivier c. J Med Chem. 1998 Dec 3;41(25):5002-11. doi: 10.1021/jm980350k. J Med Chem. 1998. PMID: 9836618
We hypothesized that covalent constraints such as side-chain to side-chain lactam rings would stabilize an alpha-helical conformation shown to be important for the recognition and binding of the human corticotropin-releasing factor (hCRF) C-terminal 33 residues to CRF rece …
We hypothesized that covalent constraints such as side-chain to side-chain lactam rings would stabilize an alpha-helical conformation shown …
Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins).
Erchegyi J, Wang L, Gulyas J, Samant M, Perrin MH, Lewis K, Miller C, Vaughan J, Donaldson C, Fischer W, Low W, Yakabi S, Karasawa H, Taché Y, Rivier C, Rivier J. Erchegyi J, et al. Among authors: rivier j, rivier c. J Med Chem. 2016 Feb 11;59(3):854-66. doi: 10.1021/acs.jmedchem.5b00926. Epub 2016 Feb 3. J Med Chem. 2016. PMID: 26789203 Free PMC article.
Betidamino acid scan of the GnRH antagonist acyline.
Jiang G, Miller C, Koerber SC, Porter J, Craig AG, Bhattacharjee S, Kraft P, Burris TP, Campen CA, Rivier CL, Rivier JE. Jiang G, et al. Among authors: rivier je, rivier cl. J Med Chem. 1997 Nov 7;40(23):3739-48. doi: 10.1021/jm970024p. J Med Chem. 1997. PMID: 9371239
376 results