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Page 1
Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity.
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schäfer H, Gudermann T, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 2003 Sep;88(9):4258-67. doi: 10.1210/jc.2003-030233. J Clin Endocrinol Metab. 2003. PMID: 12970296 Free article. Clinical Trial.
Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes.
Rosenkranz K, Hinney A, Ziegler A, von Prittwitz S, Barth N, Roth H, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt M, Schäfer H, Remschmidt H, Hebebrand J. Rosenkranz K, et al. Among authors: siegfried w. Int J Obes Relat Metab Disord. 1998 Feb;22(2):157-63. doi: 10.1038/sj.ijo.0800550. Int J Obes Relat Metab Disord. 1998. PMID: 9504324
Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 1998 Oct;83(10):3737-41. doi: 10.1210/jcem.83.10.5298. J Clin Endocrinol Metab. 1998. PMID: 9768693
No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region.
Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Hermann H, Herpertz-Dahlmann BM, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. Mol Psychiatry. 1998 Nov;3(6):539-43. doi: 10.1038/sj.mp.4000394. Mol Psychiatry. 1998. PMID: 9857981
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.
Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. J Clin Endocrinol Metab. 1999 Apr;84(4):1483-6. doi: 10.1210/jcem.84.4.5728. J Clin Endocrinol Metab. 1999. PMID: 10199800
No evidence for an involvement of alleles of polymorphisms in the serotonin1Dbeta and 7 receptor genes in obesity, underweight or anorexia nervosa.
Hinney A, Herrmann H, Löhr T, Rosenkranz K, Ziegler A, Lehmkuhl G, Poustka F, Schmidt MH, Mayer H, Siegfried W, Remschmidt H, Hebebrand J. Hinney A, et al. Among authors: siegfried w. Int J Obes Relat Metab Disord. 1999 Jul;23(7):760-3. doi: 10.1038/sj.ijo.0800926. Int J Obes Relat Metab Disord. 1999. PMID: 10454111
79 results