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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.
Zhang WB, Navenot JM, Haribabu B, Tamamura H, Hiramatu K, Omagari A, Pei G, Manfredi JP, Fujii N, Broach JR, Peiper SC. Zhang WB, et al. Among authors: manfredi jp. J Biol Chem. 2002 Jul 5;277(27):24515-21. doi: 10.1074/jbc.M200889200. Epub 2002 Mar 28. J Biol Chem. 2002. PMID: 11923301 Free article.
Identification of allosteric peptide agonists of CXCR4.
Sachpatzidis A, Benton BK, Manfredi JP, Wang H, Hamilton A, Dohlman HG, Lolis E. Sachpatzidis A, et al. Among authors: manfredi jp. J Biol Chem. 2003 Jan 10;278(2):896-907. doi: 10.1074/jbc.M204667200. Epub 2002 Nov 3. J Biol Chem. 2003. PMID: 12417595 Free article.
18 results