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Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Sawyer JS, Bach NJ, Baker SR, Baldwin RF, Borromeo PS, Cockerham SL, Fleisch JH, Floreancig P, Froelich LL, Jackson WT, et al. Sawyer JS, et al. Among authors: jackson wt. J Med Chem. 1995 Oct 27;38(22):4411-32. doi: 10.1021/jm00022a006. J Med Chem. 1995. PMID: 7473568
o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists.
Sofia MJ, Floreancig P, Bach NJ, Baker SR, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, et al. Sofia MJ, et al. Among authors: jackson wt. J Med Chem. 1993 Nov 26;36(24):3978-81. doi: 10.1021/jm00076a029. J Med Chem. 1993. PMID: 7902871 No abstract available.
Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor.
Fleisch JH, Armstrong CT, Roman CR, Mihelich ED, Spaethe SM, Jackson WT, Bobbitt JL, Draheim S, Bach NJ, Dillard RD, Martinelli M, Fouts R, Snyder DW. Fleisch JH, et al. Among authors: jackson wt. J Pharmacol Exp Ther. 1996 Jul;278(1):252-7. J Pharmacol Exp Ther. 1996. PMID: 8764358
235 results