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Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Sawyer JS, Bach NJ, Baker SR, Baldwin RF, Borromeo PS, Cockerham SL, Fleisch JH, Floreancig P, Froelich LL, Jackson WT, et al. Sawyer JS, et al. J Med Chem. 1995 Oct 27;38(22):4411-32. doi: 10.1021/jm00022a006. J Med Chem. 1995. PMID: 7473568
The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.
Sofia MJ, Floreancig P, Bach N, Baker SR, Nelson K, Sawyer JS, Baldwin R, Cockerham SL, Fleisch JH, Froelich LL, Jackson WT, Marder P, Roman CR, Saussy DL Jr, Silbaugh SA, Spaethe SM, Stengel PW. Sofia MJ, et al. Among authors: sawyer js. Adv Exp Med Biol. 1997;400A:381-6. doi: 10.1007/978-1-4615-5325-0_51. Adv Exp Med Biol. 1997. PMID: 9547580 No abstract available.
34 results