Stein H - Search Results

1

Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.

Shen W, Garvey DS, Cohen J, Stein H, Rosenberg SH. Shen W, et al. Among authors: stein h. Bioorg Med Chem Lett. 1998 Apr 21;8(8):891-6. doi: 10.1016/s0960-894x(98)00143-7. Bioorg Med Chem Lett. 1998. PMID: 9871507

2

Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.

Rosenberg SH, Woods KW, Sham HL, Kleinert HD, Martin DL, Stein H, Cohen J, Egan DA, Bopp B, Merits I, et al. Rosenberg SH, et al. Among authors: stein h. J Med Chem. 1990 Jul;33(7):1962-9. doi: 10.1021/jm00169a024. J Med Chem. 1990. PMID: 2194033

3

Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue.

Rosenberg SH, Woods KW, Kleinert HD, Stein H, Nellans HN, Hoffman DJ, Spanton SG, Pyter RA, Cohen J, Egan DA, et al. Rosenberg SH, et al. Among authors: stein h. J Med Chem. 1989 Jun;32(6):1371-8. doi: 10.1021/jm00126a038. J Med Chem. 1989. PMID: 2657067

4

Renin inhibitors: C-terminal oxetanes as potent transition-state mimics.

Rosenberg SH, Spina KP, Stein H, Cohen J, Baker WR, Kleinert HD. Rosenberg SH, et al. Among authors: stein h. Bioorg Med Chem. 1994 Sep;2(9):927-37. doi: 10.1016/s0968-0896(00)82042-8. Bioorg Med Chem. 1994. PMID: 7712128

5

Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site.

Rosenberg SH, Dellaria JF, Kempf DJ, Hutchins CW, Woods KW, Maki RG, de Lara E, Spina KP, Stein HH, Cohen J, et al. Rosenberg SH, et al. Among authors: stein hh. J Med Chem. 1990 Jun;33(6):1582-90. doi: 10.1021/jm00168a009. J Med Chem. 1990. PMID: 2187994

6

Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites.

Kempf DJ, de Lara E, Stein HH, Cohen J, Egan DA, Plattner JJ. Kempf DJ, et al. Among authors: stein hh. J Med Chem. 1990 Jan;33(1):371-4. doi: 10.1021/jm00163a059. J Med Chem. 1990. PMID: 2404121

7

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.

Rosenberg SH, Spina KP, Woods KW, Polakowski J, Martin DL, Yao Z, Stein HH, Cohen J, Barlow JL, Egan DA, et al. Rosenberg SH, et al. Among authors: stein hh. J Med Chem. 1993 Feb 19;36(4):449-59. doi: 10.1021/jm00056a005. J Med Chem. 1993. PMID: 8474101

8

Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-72517).

Rosenberg SH, Spina KP, Condon SL, Polakowski J, Yao Z, Kovar P, Stein HH, Cohen J, Barlow JL, Klinghofer V, et al. Rosenberg SH, et al. Among authors: stein hh. J Med Chem. 1993 Feb 19;36(4):460-7. doi: 10.1021/jm00056a006. J Med Chem. 1993. PMID: 8474102

9

(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.

Fung AK, Baker WR, Fakhoury S, Stein HH, Cohen J, Donner BG, Garvey DS, Spina KP, Rosenberg SH. Fung AK, et al. Among authors: stein hh. J Med Chem. 1997 Jul 4;40(14):2123-5. doi: 10.1021/jm970058x. J Med Chem. 1997. PMID: 9216829 No abstract available.

10

New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.

Luly JR, Bolis G, BaMaung N, Soderquist J, Dellaria JF, Stein H, Cohen J, Perun TJ, Greer J, Plattner JJ. Luly JR, et al. Among authors: stein h. J Med Chem. 1988 Mar;31(3):532-9. doi: 10.1021/jm00398a008. J Med Chem. 1988. PMID: 3279206

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