Doherty A - Search Results

1

Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1).

Massa MA, Patt WC, Ahn K, Sisneros AM, Herman SB, Doherty A. Massa MA, et al. Among authors: doherty a. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2117-22. doi: 10.1016/s0960-894x(98)00375-8. Bioorg Med Chem Lett. 1998. PMID: 9873497

2

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: doherty am. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

3

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al. Doherty AM, et al. J Med Chem. 1995 Apr 14;38(8):1259-63. doi: 10.1021/jm00008a002. J Med Chem. 1995. PMID: 7731010 No abstract available.

4

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM. Patt WC, et al. Among authors: doherty am. J Med Chem. 1997 Mar 28;40(7):1063-74. doi: 10.1021/jm9606507. J Med Chem. 1997. PMID: 9089328

5

Novel selective quinazoline inhibitors of endothelin converting enzyme-1.

Ahn K, Sisneros AM, Herman SB, Pan SM, Hupe D, Lee C, Nikam S, Cheng XM, Doherty AM, Schroeder RL, Haleen SJ, Kaw S, Emoto N, Yanagisawa M. Ahn K, et al. Among authors: doherty am. Biochem Biophys Res Commun. 1998 Feb 4;243(1):184-90. doi: 10.1006/bbrc.1998.8081. Biochem Biophys Res Commun. 1998. PMID: 9473502

6

Butenolide endothelin antagonists with improved aqueous solubility.

Patt WC, Cheng XM, Repine JT, Lee C, Reisdorph BR, Massa MA, Doherty AM, Welch KM, Bryant JW, Flynn MA, Walker DM, Schroeder RL, Haleen SJ, Keiser JA. Patt WC, et al. Among authors: doherty am. J Med Chem. 1999 Jun 17;42(12):2162-8. doi: 10.1021/jm980504w. J Med Chem. 1999. PMID: 10377221

7

Structure-activity relationships of a novel series of orally active nonpeptide ETA and ETA/B endothelin receptor-selective antagonists.

Doherty AM, Patt WC, Repine J, Edmunds JJ, Berryman KA, Reisdorph BR, Walker DM, Haleen SJ, Keiser JA, Flynn MA, et al. Doherty AM, et al. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S358-61. J Cardiovasc Pharmacol. 1995. PMID: 8587414

8

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

Berryman KA, Edmunds JJ, Bunker AM, Haleen S, Bryant J, Welch KM, Doherty AM. Berryman KA, et al. Among authors: doherty am. Bioorg Med Chem. 1998 Sep;6(9):1447-56. doi: 10.1016/s0968-0896(98)00080-7. Bioorg Med Chem. 1998. PMID: 9801816

9

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.

Cody WL, Augelli-Szafran CE, Berryman KA, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Penvose-Yi J, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, Leblond L, Winocour PD, Siddiqui MA. Cody WL, et al. Among authors: doherty am. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2503-8. doi: 10.1016/s0960-894x(99)00419-9. Bioorg Med Chem Lett. 1999. PMID: 10498197

10

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

Doherty AM, Sircar I, Kornberg BE, Quin J 3rd, Winters RT, Kaltenbronn JS, Taylor MD, Batley BL, Rapundalo SR, Ryan MJ, et al. Doherty AM, et al. J Med Chem. 1992 Jan;35(1):2-14. doi: 10.1021/jm00079a001. J Med Chem. 1992. PMID: 1732531

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