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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.
Hatse S, Princen K, De Clercq E, Rosenkilde MM, Schwartz TW, Hernandez-Abad PE, Skerlj RT, Bridger GJ, Schols D. Hatse S, et al. Among authors: skerlj rt. Biochem Pharmacol. 2005 Sep 1;70(5):752-61. doi: 10.1016/j.bcp.2005.05.035. Biochem Pharmacol. 2005. PMID: 16011832 Free article.
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.
Bridger GJ, Skerlj RT, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Joao HC, Witvrouw M, De Vreese K, Pauwels R, De Clercq E. Bridger GJ, et al. Among authors: skerlj rt. J Med Chem. 1996 Jan 5;39(1):109-19. doi: 10.1021/jm950584t. J Med Chem. 1996. PMID: 8568797
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker.
Bridger GJ, Skerlj RT, Thornton D, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Yamamoto N, De Vreese K, Pauwels R, et al. Bridger GJ, et al. Among authors: skerlj rt. J Med Chem. 1995 Jan 20;38(2):366-78. doi: 10.1021/jm00002a019. J Med Chem. 1995. PMID: 7830280
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication.
Bridger GJ, Skerlj RT, Hernandez-Abad PE, Bogucki DE, Wang Z, Zhou Y, Nan S, Boehringer EM, Wilson T, Crawford J, Metz M, Hatse S, Princen K, De Clercq E, Schols D. Bridger GJ, et al. Among authors: skerlj rt. J Med Chem. 2010 Feb 11;53(3):1250-60. doi: 10.1021/jm901530b. J Med Chem. 2010. PMID: 20043638
45 results