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Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.
Greenspan PD, Clark KL, Tommasi RA, Cowen SD, McQuire LW, Farley DL, van Duzer JH, Goldberg RL, Zhou H, Du Z, Fitt JJ, Coppa DE, Fang Z, Macchia W, Zhu L, Capparelli MP, Goldstein R, Wigg AM, Doughty JR, Bohacek RS, Knap AK. Greenspan PD, et al. Among authors: coppa de. J Med Chem. 2001 Dec 20;44(26):4524-34. doi: 10.1021/jm010206q. J Med Chem. 2001. PMID: 11741472
N-arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B.
Greenspan PD, Clark KL, Cowen SD, McQuire LW, Tommasi RA, Farley DL, Quadros E, Coppa DE, Du Z, Fang Z, Zhou H, Doughty J, Toscano KT, Wigg AM, Zhou S. Greenspan PD, et al. Among authors: coppa de. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4121-4. doi: 10.1016/j.bmcl.2003.08.006. Bioorg Med Chem Lett. 2003. PMID: 14592520