New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis.
Nomura T, Ueda M, Tasaki M, Misumi Y, Masuda T, Inoue Y, Tsuda Y, Okada M, Okazaki T, Kanenawa K, Isoguchi A, Nakamura M, Obayashi K, Shinriki S, Matsui H, Yamashita T, Ando Y.
Nomura T, et al.
Orphanet J Rare Dis. 2019 May 27;14(1):116. doi: 10.1186/s13023-019-1100-y.
Orphanet J Rare Dis. 2019.
PMID: 31133063
Free PMC article.
BACKGROUND: Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is caused by a variant transthyretin (TTR), which is a serum protein secreted by the liver. Mass spectrometry (MS) is a useful tool that can detect variant TTRs in serum samples from patients with ATTRv a …
BACKGROUND: Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is caused by a variant transthyretin (TTR), which is a serum protein se …