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Lack of myostatin results in excessive muscle growth but impaired force generation.
Amthor H, Macharia R, Navarrete R, Schuelke M, Brown SC, Otto A, Voit T, Muntoni F, Vrbóva G, Partridge T, Zammit P, Bunger L, Patel K. Amthor H, et al. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1835-40. doi: 10.1073/pnas.0604893104. Epub 2007 Jan 31. Proc Natl Acad Sci U S A. 2007. PMID: 17267614 Free PMC article.
Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity.
Amthor H, Otto A, Vulin A, Rochat A, Dumonceaux J, Garcia L, Mouisel E, Hourdé C, Macharia R, Friedrichs M, Relaix F, Zammit PS, Matsakas A, Patel K, Partridge T. Amthor H, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7479-84. doi: 10.1073/pnas.0811129106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383783 Free PMC article.