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Cross-reactivity of ten anti-prostate-specific antigen monoclonal antibodies with human glandular kallikrein.
Corey E, Buhler KR, Vessella RL. Corey E, et al. Urology. 1997 Oct;50(4):567-71; discussion 571-2. doi: 10.1016/S0090-4295(97)00415-9. Urology. 1997. PMID: 9338733
However, no combination of mAbs tested in sandwich assays exhibited a signal in hK2 cross-reactivity experiments greater than 0.1% of the PSA signal. CONCLUSIONS: We have evaluated 10 anti-PSA mAbs and determined that despite the 80% homology between PSA and hK2 proteins, …
However, no combination of mAbs tested in sandwich assays exhibited a signal in hK2 cross-reactivity experiments greater than 0.1% of …
Characterization of 10 new monoclonal antibodies against prostate-specific antigen by analysis of affinity, specificity and function in sandwich assays.
Corey E, Wegner SK, Stray JE, Corey MJ, Arfman EW, Lange PH, Vessella RL. Corey E, et al. Int J Cancer. 1997 Jun 11;71(6):1019-28. doi: 10.1002/(sici)1097-0215(19970611)71:6<1019::aid-ijc18>3.0.co;2-8. Int J Cancer. 1997. PMID: 9185706
While prostate-specific antigen (PSA) is already an invaluable marker for prostate cancer, there is continuing demand for new anti-PSA antibodies with specific characteristics, e.g., high sensitivity and specificity and equimolar binding to free PSA (f-PSA) and the PSA-alpha-1 …
While prostate-specific antigen (PSA) is already an invaluable marker for prostate cancer, there is continuing demand for new anti-PSA antib …
Prostate-specific antigen: characterization of epitopes by synthetic peptide mapping and inhibition studies.
Corey E, Wegner SK, Corey MJ, Vessella RL. Corey E, et al. Clin Chem. 1997 Apr;43(4):575-84. Clin Chem. 1997. PMID: 9105257
We also examined the ability of the mAbs to inhibit PSA enzymatic activity and block the association of PSA with alpha 1-antichymotrypsin (ACT). Linear epitope mapping with a polyclonal antibody indicated the presence of six major antigenic regions in PSA. ...
We also examined the ability of the mAbs to inhibit PSA enzymatic activity and block the association of PSA with alpha 1-antichymotry …