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Page 1
High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity.
King GD, Muhammad AK, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. King GD, et al. J Virol. 2008 May;82(9):4680-4. doi: 10.1128/JVI.00232-08. Epub 2008 Feb 20. J Virol. 2008. PMID: 18287240 Free PMC article.
Herein we demonstrate that high-capacity adenovirus vectors (HC-Ads) carrying the conditional cytotoxic gene herpes simplex virus type 1-thymidine kinase (TK) induce tumor regression and long-term survival in an intracranial glioma model, even in the presence of systemic a …
Herein we demonstrate that high-capacity adenovirus vectors (HC-Ads) carrying the conditional cytotoxic gene herpes simplex virus type 1 …
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain.
Barcia C, Thomas CE, Curtin JF, King GD, Wawrowsky K, Candolfi M, Xiong WD, Liu C, Kroeger K, Boyer O, Kupiec-Weglinski J, Klatzmann D, Castro MG, Lowenstein PR. Barcia C, et al. J Exp Med. 2006 Sep 4;203(9):2095-107. doi: 10.1084/jem.20060420. Epub 2006 Aug 21. J Exp Med. 2006. PMID: 16923851 Free PMC article.
The hallmark of immunological synapses established by T cells is the formation of the supramolecular activation clusters (SMACs), in which adhesion molecules such as leukocyte function-associated antigen 1 segregate to the peripheral domain of the immunological synapse (p- …
The hallmark of immunological synapses established by T cells is the formation of the supramolecular activation clusters (SMACs), in which a …
Gene therapy for pituitary tumors.
Seilicovich A, Pisera D, Sciascia SA, Candolfi M, Puntel M, Xiong W, Jaita G, Castro MG. Seilicovich A, et al. Curr Gene Ther. 2005 Dec;5(6):559-72. doi: 10.2174/156652305774964721. Curr Gene Ther. 2005. PMID: 16457646 Free PMC article. Review.
Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo.
Puntel M, Barrett RJ, Mondkar S, Saxena V, Kroeger KM, Muhammad AK, Liu C, Bondale N, Sciascia S, Xiong W, Shi Y, Salem A, Zadmehr A, Huynh P, Palmer D, Ng P, Castro MG, Lowenstein PR. Puntel M, et al. J Virol. 2009 Feb;83(4):2004-10. doi: 10.1128/JVI.01298-08. Epub 2008 Dec 10. J Virol. 2009. PMID: 19073729 Free PMC article.
Herein we demonstrate that herpes simplex virus type 1 (HSV1) thymidine kinase (TK) gene sequences (1,131 bp) fused to the 3' end of lacZ increase transgene expression from high-capacity adenoviral vectors (HCAd), but not from first-generation (Ad) vectors. ...
Herein we demonstrate that herpes simplex virus type 1 (HSV1) thymidine kinase (TK) gene sequences (1,131 bp) fused to the 3' …
Gene therapy and targeted toxins for glioma.
King GD, Curtin JF, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. King GD, et al. Curr Gene Ther. 2005 Dec;5(6):535-57. doi: 10.2174/156652305774964631. Curr Gene Ther. 2005. PMID: 16457645 Free PMC article. Review.
18 results