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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. Ortega-Molina A, et al. Nat Aging. 2024 Aug;4(8):1102-1120. doi: 10.1038/s43587-024-00635-x. Epub 2024 Jun 7. Nat Aging. 2024. PMID: 38849535 Free PMC article.
Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation.
Martins-Macedo J, Araújo B, Anjo SI, Silveira-Rosa T, Patrício P, Alves ND, Silva JM, Teixeira FG, Manadas B, Rodrigues AJ, Lepore AC, Salgado AJ, Gomes ED, Pinto L. Martins-Macedo J, et al. Mol Psychiatry. 2024 Jul;29(7):2185-2198. doi: 10.1038/s41380-024-02490-z. Epub 2024 Mar 7. Mol Psychiatry. 2024. PMID: 38454085 Free PMC article.
Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.
Vila-Castelar C, Akinci M, Palpatzis E, Aguilar-Dominguez P, Operto G, Kollmorgen G, Quijano-Rubio C, Blennow K, Zetterberg H, Falcon C, Fauria K, Gispert JD, Grau-Rivera O, Suárez-Calvet M, Arenaza-Urquijo EM; ALFA study. Vila-Castelar C, et al. Mol Psychiatry. 2024 Oct 9. doi: 10.1038/s41380-024-02753-9. Online ahead of print. Mol Psychiatry. 2024. PMID: 39384963