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Alpha1-adrenergic blockers selectively antagonize the contractions induced by 6-nitrodopamine in the human vas deferens.
Britto-Júnior J, Guimarães RAB, Oliveira DL, Lima AT, Quirino Junior G, de Oliveira Stocco GA, Salgado Uramoto EH, Fregonesi A, Antunes E, De Nucci G. Britto-Júnior J, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):3227-3238. doi: 10.1007/s00210-023-02805-x. Epub 2023 Nov 1. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37910185
The negative chronotropic effects of (±)-propranolol and (±)-4-NO2-propranolol in the rat isolated right atrium are due to blockade of the 6-nitrodopamine receptor.
Oliveira DL, Cardoso VF, Britto-Júnior J, Fuguhara V, Frecentese F, Sparaco R, Santagada V, Caliendo G, Pupo AS, Antunes E, De Nucci G. Oliveira DL, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct 9. doi: 10.1007/s00210-024-03463-3. Online ahead of print. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 39382679