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Unraveling the 2,3-diketo-L-gulonic acid-dependent and -independent impacts of L-ascorbic acid on somatic cell reprogramming.
Liang L, He M, Zhang Y, Wang C, Qin Z, Li Q, Yang T, Meng F, Zhou Y, Ge H, Song W, Chen S, Dong L, Ren Q, Li C, Guo L, Sun H, Zhang W, Pei D, Zheng H. Liang L, et al. Cell Biosci. 2023 Nov 30;13(1):218. doi: 10.1186/s13578-023-01160-x. Cell Biosci. 2023. PMID: 38037169 Free PMC article.
RESULTS: Asc exhibited dual capabilities in promoting reprogramming through both 2,3-diketo-L-gulonic acid (DKG), a key metabolite during Asc degradation, dependent and independent routes. On the one hand, Asc facilitated reprogramming by promoting cell proliferation and i …
RESULTS: Asc exhibited dual capabilities in promoting reprogramming through both 2,3-diketo-L-gulonic acid (DKG), a key metabolite du …
Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex.
Li Y, Yang T, Cheng Y, Hou J, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP, Zheng H. Li Y, et al. Cell Prolif. 2023 May;56(5):e13422. doi: 10.1111/cpr.13422. Epub 2023 Feb 14. Cell Prolif. 2023. PMID: 36786003 Free PMC article.
In addition, to optimize the delivery of the transdifferentiation medium, three key growth factors, insulin, bFGF and transferrin, were loaded onto chitosan nanoparticles, mixed with gelatin methacryloyl and tested in animals with motor cortex injury. ...Differences in cel …
In addition, to optimize the delivery of the transdifferentiation medium, three key growth factors, insulin, bFGF and transferrin, we …