223107/WT_/Wellcome Trust/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2023	9
2024	5

1

ADP-ribosylation from molecular mechanisms to therapeutic implications.

Suskiewicz MJ, Prokhorova E, Rack JGM, Ahel I. Suskiewicz MJ, et al. Cell. 2023 Oct 12;186(21):4475-4495. doi: 10.1016/j.cell.2023.08.030. Cell. 2023. PMID: 37832523 Free PMC article. Review.

2

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation.

Kar P, Chatrin C, Đukić N, Suyari O, Schuller M, Zhu K, Prokhorova E, Bigot N, Baretić D, Ahel J, Elsborg JD, Nielsen ML, Clausen T, Huet S, Niepel M, Sanyal S, Ahel D, Smith R, Ahel I. Kar P, et al. EMBO J. 2024 Jul;43(14):2929-2953. doi: 10.1038/s44318-024-00126-0. Epub 2024 Jun 4. EMBO J. 2024. PMID: 38834853 Free PMC article.

3

Updated protein domain annotation of the PARP protein family sheds new light on biological function.

Suskiewicz MJ, Munnur D, Strømland Ø, Yang JC, Easton LE, Chatrin C, Zhu K, Baretić D, Goffinont S, Schuller M, Wu WF, Elkins JM, Ahel D, Sanyal S, Neuhaus D, Ahel I. Suskiewicz MJ, et al. Nucleic Acids Res. 2023 Aug 25;51(15):8217-8236. doi: 10.1093/nar/gkad514. Nucleic Acids Res. 2023. PMID: 37326024 Free PMC article.

4

Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L.

Zhu K, Chatrin C, Suskiewicz MJ, Aucagne V, Foster B, Kessler BM, Gibbs-Seymour I, Ahel D, Ahel I. Zhu K, et al. EMBO Rep. 2024 Oct;25(10):4172-4189. doi: 10.1038/s44319-024-00235-1. Epub 2024 Sep 6. EMBO Rep. 2024. PMID: 39242775 Free PMC article.

5

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage.

Smith R, Zentout S, Rother M, Bigot N, Chapuis C, Mihuț A, Zobel FF, Ahel I, van Attikum H, Timinszky G, Huet S. Smith R, et al. Nat Struct Mol Biol. 2023 May;30(5):678-691. doi: 10.1038/s41594-023-00977-x. Epub 2023 Apr 27. Nat Struct Mol Biol. 2023. PMID: 37106138

6

Chemoenzymatic and Synthetic Approaches To Investigate Aspartate- and Glutamate-ADP-Ribosylation.

Tashiro K, Wijngaarden S, Mohapatra J, Rack JGM, Ahel I, Filippov DV, Liszczak G. Tashiro K, et al. J Am Chem Soc. 2023 Jun 28;145(25):14000-14009. doi: 10.1021/jacs.3c03771. Epub 2023 Jun 14. J Am Chem Soc. 2023. PMID: 37315125 Free PMC article.

7

Molecular basis for the reversible ADP-ribosylation of guanosine bases.

Schuller M, Raggiaschi R, Mikolcevic P, Rack JGM, Ariza A, Zhang Y, Ledermann R, Tang C, Mikoc A, Ahel I. Schuller M, et al. Mol Cell. 2023 Jul 6;83(13):2303-2315.e6. doi: 10.1016/j.molcel.2023.06.013. Epub 2023 Jun 29. Mol Cell. 2023. PMID: 37390817 Free PMC article.

8

The function and regulation of ADP-ribosylation in the DNA damage response.

Duma L, Ahel I. Duma L, et al. Biochem Soc Trans. 2023 Jun 28;51(3):995-1008. doi: 10.1042/BST20220749. Biochem Soc Trans. 2023. PMID: 37171085 Free PMC article.

9

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors.

Schuller M, Zarganes-Tzitzikas T, Bennett J, De Cesco S, Fearon D, von Delft F, Fedorov O, Brennan PE, Ahel I. Schuller M, et al. Pathogens. 2023 Feb 15;12(2):324. doi: 10.3390/pathogens12020324. Pathogens. 2023. PMID: 36839595 Free PMC article.

10

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions.

Zentout S, Imburchia V, Chapuis C, Duma L, Schützenhofer K, Prokhorova E, Ahel I, Smith R, Huet S. Zentout S, et al. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2322689121. doi: 10.1073/pnas.2322689121. Epub 2024 Jun 12. Proc Natl Acad Sci U S A. 2024. PMID: 38865276 Free PMC article.

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